A new collaborative study involving DPAG's Wilson and Goberdhan Groups and the Nuffield Department of Surgical Sciences (NDS) has revealed surprising parallels between \u2018prostate\u2019 cells in flies and cancer patients.
The release of dopamine in the brain plays a key role in determining how we respond when we perceive a potential reward or benefit. But so far little has been understood about the mechanism behind this. A new collaborative paper from Prof Stephanie Cragg's Group and Prof Ed Mann published in Nature Communications has uncovered a dominant regulator of the dynamics of dopamine output.
Professor Zolt\u00e1n Moln\u00e1r has edited a special issue of Journal of Anatomy with Dr Gavin Clowry from the University of Newcastle on Human Brain Development. This issue contains 15 original articles, an overview and an editorial on Human Brain Development.
Thousands of genes are involved in the regulation of our day-to-day metabolism and relatively little is understood about their function. One key protein, an ABC Transporter called ABCC5, has recently been predicted to be a susceptibility gene for Type 2 diabetes. In a new study selected as Editor's Choice in Obesity, Associate Professor Heidi de Wet has confirmed ABCC5's role in energy metabolism and identified the mechanism behind its metabolic impact for the first time.
A collaborative paper from the De Val and Smart Groups has established multiple regulatory pathways responsible for the formation of blood vessels in the developing heart. In doing so they have identified a crucial pathway that is repressed in the adult heart after injury, which may hold the key to a new and improved strategy for repair.
Associate Professor Vladyslav Vyazovskiy has co-authored a paper based on a pioneering sleep study led by Oxford Brookes researchers. Their research into a nocturnal primate performed in the wild is the first of its kind and could enhance our understanding of human sleep.
During the emergency procedure used to reopen the blocked artery causing a heart attack, smaller \"micro\" blood vessels can remain constricted causing significant damage. A new study led by Associate Professor Neil Herring and published in the European Heart Journal has established a key cause behind this constriction and identified a potential therapeutic target to block the mechanism behind it.
A collaborative King Group study published today in Nature Communications enhances our understanding of how our brains learn to adapt to abnormal sensory changes such as hearing loss. Their results could inform the future development of devices that restore hearing or other sensory impairments.
Professor Zolt\u00e1n Moln\u00e1r has co-written an insightful paper into the story of preeminent neuroscientist Santiago Ram\u00f3n y Cajal's delivery of the Croonian Lecture over a century ago and his interactions with Sir Charles Sherrington, our former Waynflete Professor of Physiology.
Research carried out by Postdoctoral Research Scientist Jacinta Kalisch-Smith during her PhD, now published in Development, reveals key insights into the effects of alcohol in the very early stages of pregnancy, a stage during which a mother is unlikely to know she is pregnant.
Research led by Postdoctoral Research Scientist Dr Elizabeth Haythorne and published in Nature Communications sheds light on a vicious cycle that causes specialised cells to fail in their function to maintain healthy bloody sugar levels.
A new discovery from the Lakhal-Littleton Group on how iron deficiency affects the vasculature of the lung could hold the key to improving treatment of pulmonary arterial hypertension.
Dr Oliver Stone\u2019s paper \u201cParaxial mesoderm is the major source of lymphatic endothelium\u201d published in Developmental Cell reveals the earliest known step in the formation of the lymphatic vasculature.
Preparing media for tissue culture, but not sure how to get it to the right pH? Worried about pH changes during your incubations? DPAG Group publishes recommendations for best practice in controlling and managing pH under culture conditions.
The revised and updated \"Human Metabolism: A Regulatory Perspective\" offers a new and integrated review of metabolism and metabolic regulation, where difficult concepts are explained in clear and concise terms to provide an accessible and essential guide to the topic.
The Wade-Martins Group has identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment.
A new study from OPDC Career Development Fellow Natalie Connor-Robson investigates how mutations in the gene LRRK2, which are known to cause Parkinson\u2019s, affect normal cell function.
Dr Kerry Walker and her team help us to better understand how we perceive pitch, a feature of hearing critical to recognising communication through sound, such as speech and music.
The Miesenb\u00f6ck Group have discovered a brain process common to sleep and ageing in research that could pave the way for new treatments for insomnia.
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