{ "items": [ "\n\n
\n \n 8 March 2023\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Wilson Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nCollaborative work from DPAG and Oncology researchers has revealed a potential new pathway to block the production of a specific group of exosomes made in the cell\u2019s recycling system that can promote the growth of cancerous tumours.
\n \n\n\n \n 31 January 2023\n \n
\n\n \n\n \n\n \n \n \n \n Cardiac Theme\n \n \n \n \n Herring Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nResearchers from the Herring group have developed a blood test that measures stress hormone levels after heart attacks. The test \u2013 costing just \u00a310 \u2013 could ensure patients receive timely life-saving treatment.
\n \n\n\n \n 13 December 2022\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Vyazovskiy Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study, co-authored by Professor Vladyslav Vyazovskiy, published in Nature Neuroscience, has revealed that intracellular chloride levels within cortical pyramidal neurons reflect sleep\u2013wake history.
\n \n\n\n \n 14 November 2022\n \n
\n\n \n\n \n\n \n \n \n \n Ashcroft Group News\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nResearch led by Dr Elizabeth Haythorne and Professor Frances Ashcroft reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes. They have discovered that glucose metabolites, rather than glucose itself, are key to the progression of type 2 diabetes. Glucose metabolites damage pancreatic beta-cell function, so they are unable to release enough of the hormone insulin. Reducing the rate at which glucose is metabolised, and these glucose metabolites build up, can prevent the effects of hyperglycaemia.
\n \n\n\n \n 10 November 2022\n \n
\n\n \n\n \n\n \n \n \n \n OPDC News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Wade-Martins Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nEstablishing preclinical models of Alzheimer\u2019s that reflect in-life clinical symptoms of each individual is a critically important goal, yet so far it has not been fully realised. A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer\u2019s brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons.
\n \n\n\n \n 3 November 2022\n \n
\n\n \n\n \n\n \n \n \n \n Domingos Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new review from Professor Ana Domingos\u2019 lab and colleagues offers a fresh modern viewpoint on sympathetic neurons and their relation to immune cells and obesity.
\n \n\n\n \n 5 October 2022\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA collaborative DPAG-led study studied patients at six and twelve months after COVID-19 infection, finding that prior COVID-19 infection was associated with more uneven inflation of the lungs during normal breathing. There was also an association between hospitalisation with COVID-19 and smaller lung volumes, and admission to the intensive care unit (ICU) was associated with an enlarged respiratory dead space.
\n \n\n\n \n 30 September 2022\n \n
\n\n \n\n \n\n \n \n \n \n Bruno Group News\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study from the Bruno Group is challenging our perceptions of how the different regions of the cerebral cortex function. A group of \u2018quiet\u2019 cells in the somatosensory cortex that rarely respond to touch have been found to react mainly to surprising circumstances. The results suggest their function is not necessarily driven by touch, but may indicate an important and previously unidentified role across all the major cortices.
\n \n\n\n \n 16 September 2022\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nSwietach Group scientists have identified a rescue mechanism that allows cancers to overcome the consequences of inactivating mutations in critically important genes.
\n \n\n\n \n 21 June 2022\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nDPAG\u2019s auditory neuroscience researchers have found that the auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to remove reverberation.
\n \n\n\n \n 13 April 2022\n \n
\n\n \n\n \n\n \n \n \n \n Cardiac Theme\n \n \n \n \n Cell Physiology\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nResearch led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.
\n \n\n\n \n 8 April 2022\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nPhantom percepts, such as subjective tinnitus, are driven by fundamental changes in spontaneous brain activity. Sleep is a natural example of major shifts in spontaneous brain activity and perceptual state, suggesting an interaction between sleep and tinnitus that has so far been little considered. In a new collaborative review article from DPAG\u2019s auditory and sleep neuroscientists, tinnitus and sleep research is brought together for the first time, and, in conclusion, they propose a fundamental relationship between natural brain dynamics and the expression and pathogenesis of tinnitus.
\n \n\n\n \n 7 April 2022\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Klemm Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new Klemm Lab-led paper has uncovered a new mechanism involving the endoplasmic reticulum that is critical to the organisation and position of the microtubule (MT) cytoskeleton, which ultimately dictates the shape and function of our body\u2019s cells.
\n \n\n\n \n 28 March 2022\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Vyazovskiy Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nA new DPAG-led review paper, published in the journal Brain, has shown that a poorly understood region of the brain called the claustrum may play an important role in how we experience pain.
\n \n\n\n \n 25 March 2022\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new Novo Nordisk project paper has uncovered the role of ACC1 enzyme in the regulation of glucagon secretion for the first time. This raises the prospect of a potential new therapeutic target in the context of type 2 diabetes and metabolic disorders characterised by hyperglycaemia.
\n \n\n\n \n 11 March 2022\n \n
\n\n \n\n \n\n \n \n \n \n Cell Physiology\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new paper led by Dr Johanna Michl and Professor Pawel Swietach from DPAG\u2019s Swietach Group has identified a new gene that allows cancer cells to survive in the typically acidic microenvironment of a malignant tumour. They have discovered drugs that inhibit the gene in other medical conditions also selectively kill cancer cells at acidic pH, without damaging healthy tissue. This defines a novel strategy for targeting acidic tumour regions.
\n \n\n\n \n 11 March 2022\n \n
\n\n \n\n \n\n \n \n \n \n Cragg Group News\n \n \n \n \n OPDC News\n \n \n \n \n Postdoctoral\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new study from Dr Yanfeng Zhang has uncovered the first evidence that dopamine-dependent long-term potentiation is also gated by the pause of striatal cholinergic interneurons and the depolarisation of the striatal spiny projection neurons. This discovery overturns previous ideas that the phasic dopamine release is the only factor gate corticostriatal synaptic plasticity, thus changing our understanding of dopamine functions in reinforcement learning.
\n \n\n\n \n 18 February 2022\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Molnar Group News\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n\n \n\n\n
\n \n\n \n \n \nA new paper from the Moln\u00e1r Group has shed light on substantial rewiring of corticothalamic connections that is triggered by early sensory loss during development. The study has identified a new mechanism that significantly rearranges the cortico-thalamo-cortical circuits but has not been considered before in patients with sensory loss for potential therapies.
\n \n\n\n \n 17 January 2022\n \n
\n\n \n\n \n\n \n \n \n \n Integrative Neuroscience\n \n \n \n \n Molnar Group News\n \n \n \n \n Publication\n \n \n\n \n\n\n
\n \n\n \n \n \nA pioneering book from Professor Zolt\u00e1n Moln\u00e1r and Yale Professors Tamas Horvath and Joy Hirsch to be released on 1 February 2022 addresses the fundamental relationship between the body, brain and behaviour.
\n \n\n\n \n 16 December 2021\n \n
\n\n \n\n \n\n \n \n \n \n Publication\n \n \n \n \n Research\n \n \n \n \n Vyazovskiy Group News\n \n \n\n \n\n\n
\n \n\n \n \n \nNew collaborative research led by the Vyazovskiy Group has shed new light on the role of the hypothalamus in the transition between sleep and wake states.
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