Kaitlyn Dennis, Ujang Purnama and Kerstin Timm have won prizes across each of the three award categories at this year\u2019s Society for Heart and Vascular Metabolism conference, demonstrating DPAG's continued excellence in cardiac metabolism research.
Dr Richard Tyser is this year\u2019s winner of the Bernard and Joan Marshall Early Career Investigator Prize, and Dr Jack Miller has received a runner-up award, at the British Society of Cardiovascular Research Autumn Meeting.
In animal models, iron deficient mothers have a greatly increased risk of having offspring with congenital heart disease (CHD). The risk of CHD can be greatly reduced if the mother is given iron supplements very early in pregnancy. Additionally, embryos from a mouse model of Down Syndrome were particularly vulnerable to the effects of maternal iron deficiency, leading to a higher risk of developing severe heart defects.
A new collaborative project led by the Swietach group funded by the Propionic Acidemia Foundation will investigate the disease mechanisms and risk factors for cardiac disease caused by a severe inherited disorder.
New research led by Oxford BHF CRE Intermediate Transition Fellow Dr Kerstin Timm shows that a recently developed imaging technique pioneered by the Tyler Group can detect early metabolic changes in the heart caused by a commonly used chemotherapy drug, which is known to increase risk of heart failure in cancer survivors.
Associate Professor Neil Herring has been awarded a Senior Clinical Research Fellowship and a Project grant from the British Heart Foundation to further critical research into the mechanisms behind heart attacks and heart failure and potential drugs to combat them. Given the 50% reduction in research investment this year from the BHF due to the impact of COVID-19, Prof Herring is to be congratulated on these awards.
Congratulations are in order for Associate Professor Samira Lakhal-Littleton, who has been awarded a Senior Non-Clinical Fellowship by the Medical Research Council to further her lab's work exploring the implications of the cardiac hepcidin/ferroportin axis for the management of iron deficiency in heart failure.
A new paper from the Heather and Tyler groups has uncovered the mechanism responsible for reduced energy in the hearts of patients with type 2 diabetes and revealed a new therapeutic strategy to reverse the energy deficit.
Congratulations are in order for DPhil student Oliver Neely of the Paterson and Domingos labs, who has been awarded the Peter Beaconsfield Prize in Physiological Sciences 2020.
DPAG researchers have collaborated on an international study that demonstrates a detailed mechanistic understanding of how the anti-malaria drug, Hydroxychloroquine, combined with antibiotics, can cause adverse cardiac side-effects in COVID-19 patients. This gives weight to US Federal advice against using this combined treatment.
DPAG's Dr Jakub Tomek and Professor Blanca Rodriguez's Computational Cardiovascular Science Team have developed a new computer model that recreates the electrical activity of the ventricles in a human heart. In doing so, they have uncovered and resolved theoretical inconsistencies that have been present in almost all models of the heart from the last 25 years and created a new human heart model that could enable more basic, translational and clinical research into a range of heart diseases and potentially accelerate the development of new therapies.
For many years, we have been using beta-blockers to neutralise a specific stress hormone and prevent dangerous heart rhythms following a heart attack. However, a new study led by Associate Professor Neil Herring and published in the European Heart Journal has uncovered evidence for an additional stress hormone acting as a key trigger for dangerous heart rhythms that is not currently targeted by these drugs.
UCLA Researchers in collaboration with DPAG researchers from the Paterson and Herring Groups have identified a biomarker for increased risk of early mortality in patients with heart failure. Associate Professor Neil Herring is senior author.
Congratulations are in order to Matthew Kerr, Andia Redpath, Susann Bruche, KC Park and Minahil Mujahid for their achievements at this major showcase for Oxford's British Heart Foundation funded Researchers.
The award recognises and solidifies Professor Tyler's collaborative work with the MR Research Centre, part of the Department of Clinical Medicine at the University of Aarhus.
During the emergency procedure used to reopen the blocked artery causing a heart attack, smaller \"micro\" blood vessels can remain constricted causing significant damage. A new study led by Associate Professor Neil Herring and published in the European Heart Journal has established a key cause behind this constriction and identified a potential therapeutic target to block the mechanism behind it.
The Department's third and final theme day of the year culminated in a series of exciting internal talks from a diverse range of research groups covering all aspects of integrative physiology. From diabetes to iron deficiency, from pH physiology to cancer cells, the talks showcased the huge breadth of science studied across DPAG.
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