Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Prof. Matthew Wood and Dr. Samir El Andaloussi, both of DPAG, have been awarded a new £1m grant from the MRC to study gene therapy for Huntington’s Disease.

Huntington’s is a devastating disorder caused by mutations in a single gene, which result in production of a toxic protein. This protein accumulates in the brain, resulting in the progressive degeneration of nerve and muscle cells leading to death, on average within 25 years of diagnosis.

The Oxford researchers hope to employ a type of naturally occurring cell transport method, called exosomes, to deliver gene therapy directly to the brain. They will test their approach in a mouse model of the disease in the hope of proving that this could be a potential mechanism of delivering human therapy.

Similar stories

New evidence for how our brains handle surprise

A new study from the Bruno Group is challenging our perceptions of how the different regions of the cerebral cortex function. A group of ‘quiet’ cells in the somatosensory cortex that rarely respond to touch have been found to react mainly to surprising circumstances. The results suggest their function is not necessarily driven by touch, but may indicate an important and previously unidentified role across all the major cortices.

Professor Dame Sue Black to deliver 2022 Christmas Lectures

In the 2022 Christmas Lectures from the Royal Institution, DPAG's Visiting Professor of Forensic Anatomy Dame Sue Black will share secrets of forensic science.

Researchers describe how cancer cells can defend themselves from the consequences of certain genetic defects

Swietach Group scientists have identified a rescue mechanism that allows cancers to overcome the consequences of inactivating mutations in critically important genes.

Randy Bruno and Scott Waddell receive Wellcome Discovery Awards

Congratulations are in order for Professors Randy Bruno and Scott Waddell who have each been awarded a prestigious Wellcome Trust Discovery Award to significantly enhance our understanding of higher cognitive functions.

Researchers discover novel form of adaptation in the auditory system

DPAG’s auditory neuroscience researchers have found that the auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to remove reverberation.