New Paper on Layer 6b published by Professor Zoltan Molnar and colleagues in Neuron
15 December 2023
Molnar Group News Publication Research
Professor Zoltan Molnar has collaborated with colleagues on a new paper in Neuron.
Breakthrough Insights: Diffusion-Limited Oxygen Release from Stored Blood Unveiled in New Article
5 December 2023
In a new article published in Blood, the journal of the American Society of Hematology, researchers from the Department of Physiology, Anatomy, and Genetics (DPAG) and The Nuffield Department of Surgical Sciences (NDS) at the University of Oxford present compelling evidence that challenges established notions about oxygen delivery during organ perfusion.
Researchers characterise the landscape of somatic mutations among acid-base transporters in human cancers
1 December 2023
A new paper lead by DPhil student Bobby White and Professor Pawel Swietach from DPAG’s Swietach Group explores the role that somatic mutations affecting plasma membrane acid-base transporters play in human cancer evolution. The team identify acid-base transporters that are essential to cancer cell survival, and those where somatic mutations are likely to play a driving role in certain cancer types.
Pawel Swietach and KC Park publish paper in Nature Cardiovascular Research
24 November 2023
Working with collaborators from across Oxford (Thomas Milne, Nick Crump, James McCullagh, Roman Fisher, Marjorie Fournier), in Cambridge (Sophie Trefely), and at Great Ormond Street Hospital (Steve Krywawych), Pawel Swietach and KC Park working at DPAG have published a new article, 'Disrupted propionate metabolism evokes transcriptional changes in the heart by increasing histone acetylation and propionylation', in Nature Cardiovascular Research.
The King group has published a new paper in the journal eLife
9 November 2023
Professor Andrew King and members of his research group have just published a new paper ‘Hierarchical temporal prediction captures motion processing along the visual pathway’ in the journal eLife.
Pioneering new software to analyse intracellular calcium signals
1 September 2023
Cell Physiology Postdoctoral Publication Research
A collaborative team of UC Davis and University of Oxford researchers have developed an innovative new software tool – SparkMaster 2 – which will enable automatic analysis of calcium sparks which are known to cause cardiac arrythmias in a variety of disease settings. First and co-corresponding author Dr Jakub Tomek, who is a Sir Henry Wellcome Fellow based in DPAG's Zaccolo group, conducted this research as part of his fellowship year spent at UC Davis.
Researchers discover how cancer cells adapt under acidity
27 June 2023
Cell Physiology EDI News Postdoctoral Publication Research
New research led by Dr Johanna Michl and Professor Pawel Swietach has solved the longstanding mystery of how cancer cells are able to maintain a relatively alkaline intracellular pH, despite being surrounded by an acidic environment. A raised intracellular pH is required for cancer progression because it allows cancer cells to efficiently proliferate and metastasise. However, until now the exact molecular mechanism underlying this adaptation was unknown.
Failing hearts can use different fuels, and prefer fat over sugar
31 May 2023
Cardiac Theme Herring Group News Publication Research
An exciting new collaborative study from RDM and DPAG researchers has found that fat metabolism could be the key to tackling heart failure.
Researchers discover why multisensory learning is beneficial for memory
26 April 2023
CNCB Postdoctoral Publication Research
New research published in Nature, led by researchers Dr Zeynep Okray, Dr Pedro Jacob and Professor Scott Waddell at the Centre for Neural Circuits and Behaviour, has discovered a detailed neural circuit mechanism that explains how multisensory learning improves memory performance.
Old and “hangry” monocytes turn from friend to foe under assault
13 April 2023
Domingos Group News EDI News Publication Research Students
Professor Ana Domingos and DPhil student Conan O’Brien review a new study demonstrating that fasting and re-feeding causes monocytes to re-enter the bone marrow and alter the body's response to infection.
New insights into chemogenetic designer drugs to enhance our study of behaviour
10 March 2023
Publication Research Vyazovskiy Group News
A collaborative team of researchers in DPAG and Pharmacology led by Dr Lukas Krone have uncovered striking new data demonstrating that two widely used designer drugs used to turn populations of neurons on and off in the brain cause unexpected effects on sleep. These results demonstrate a critical need to improve chemogenetic approaches in behavioural studies.
Unlocking the Secrets of cAMP Signalling in the Heart: A Pathway to Targeted Therapeutics
9 March 2023
Cardiac Theme Postdoctoral Publication Research
A new Zaccolo group study has revealed key new insights into the role of cAMP signalling in both healthy and disease settings within the heart. They have identified new cAMP nanodomains in cardiac muscle cells that have far reaching implications for the treatment of heart disease.