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An in-depth look into a collaborative DPAG, Chemistry and Oxford Martin School project pioneering a radical new approach in which the brain is repaired with 3D-printed neural tissues.

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Scientists uncover hidden nerve role in deadly heart rhythm disorder

New research reveals how development and sex shape the brain

Study Reveals Unexpected Astrocyte Enlargement Enhances Brain Repair After Transplantation

Long-overlooked cerebral cortical cell layer may hold key to attention

Berlin and Oxford collaborative researchers funded by Einstein Foundation propose a new circuit theory linking a little-known cortical layer to attention and brain disorders.

A DPAG-led team introduces a new biomarker of intravascular haemolysis and a rapid, urine-based test for accessible diagnostics

Hippocampus helps us learn to navigate unknown environments, study finds

New work by the Heather and Carr groups has developed a model of human diabetic cardiomyopathy in a dish

Butt Lab publishes study on the role that cortical interneurons play in regulating sensory responses in the developing postnatal brain

New research published: How the brain conquers the third dimension

A structured, multi-scale neuronal code for economic decisions

Research shows Type V collagen from macrophages regulates initial collagen assembly and alignment in post-infarcted hearts

Research demonstrates that Cardiac lymphatics retain LYVE-1-dependent macrophages during neonatal mouse heart regeneration

Review article published: Multimodal, device-based therapeutic targeting of the cardiovascular autonomic nervous system

New research identifies Galectin-3 as a key regulator of neural development, establishing its contribution to brain growth

Professor John Stein on Visual Dyslexia

Oxford Professors Cragg and Walton celebrate publication of new book, The Handbook of Dopamine

Researchers Identify New Mechanism Linked to Early Cellular Defects in Alzheimer’s Disease

Why do we need sleep? Oxford researchers find the answer may lie in mitochondria

A New study uncovers how a metabolic “overload” in specialised brain cells triggers the need to sleep. Sleep may not just be rest for the mind - it may be essential maintenance for the body’s power supply.

New research shows cortical layers implement AI-like predictive learning

Soft microrobots bring precision drug delivery closer to clinical reality

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Interviewees

Project Collaborators

Hagan Bayley

Professor of Chemical Biology

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Linna Zhou

Oxford Martin Fellow

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Funder

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Project Website

3Dprintingforbrainrepairpage.PNG

Read more about the challenge here

Related Images

Image shows Day 13, GFAP Tuj1 vGlut1 at top, image below of brain progenitor cells differentiating into neurons and astrocytes 13 days after 3D printing.

Human brain progenitor cells differentiate into neurons and astrocytes 13 days after 3D printing.

Adapted from Zhou et al., Advanced Materials, June 2020
cortexofmutantmouse.jpg

Layer 6 (green) and layer 5 (red) of the cortex of a Pax 6 mutant mouse cerebral cortex.

Adapted from Tuoc et al., Journal of Neuroscience, July 2009
chickbrain.png

Clonally-related cells labelled in a chick brai.

Adapted from García-Moreno et al., Development, April 2014

Related Publications

New insights into the development of the human cerebral cortex.

Journal article

Molnár Z. et al, (2019), J Anat, 235, 432 - 451

High-Resolution Patterned Cellular Constructs by Droplet-Based 3D Printing.

Journal article

Graham AD. et al, (2017), Sci Rep, 7

Sip1 downstream Effector ninein controls neocortical axonal growth, ipsilateral branching, and microtubule growth and stability.

Journal article

Srivatsa S. et al, (2015), Neuron, 85, 998 - 1012

CLoNe is a new method to target single progenitors and study their progeny in mouse and chick.

Journal article

García-Moreno F. et al, (2014), Development, 141, 1589 - 1598

Selective cortical layering abnormalities and behavioral deficits in cortex-specific Pax6 knock-out mice.

Journal article

Tuoc TC. et al, (2009), J Neurosci, 29, 8335 - 8349

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Lipid‐Bilayer‐Supported 3D Printing of Human Cerebral Cortex Cells Reveals Developmental Interactions

journalarticlegraphiccropped.PNG

Bayley H. et al, (2020), Advanced Materials

greyline.PNG

A Tissue-Like Printed Material

journalarticlegraphiccropped.PNG

Bayley H. et al, (2013), Science, 340, 6128, 48-52
 

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