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New computational technique reveals changes to lung function post COVID-19 infection
Cell Physiology Publication Research
5 October 2022
A collaborative DPAG-led study studied patients at six and twelve months after COVID-19 infection, finding that prior COVID-19 infection was associated with more uneven inflation of the lungs during normal breathing. There was also an association between hospitalisation with COVID-19 and smaller lung volumes, and admission to the intensive care unit (ICU) was associated with an enlarged respiratory dead space.
BHF funded DPAG projects to receive share of £2 million raised by the London Marathon
De Val Group News Outreach Research Vieira Group News
5 October 2022
The British Heart Foundation were charity of the year for the 2022 TCS London Marathon. Around 800 BHF London Marathon runners, including former De Val lab researcher Dr Alice Preston, have raised nearly £2 million, and rising, for BHF-funded science that could lead to improved new treatments for heart failure. Research led by Associate Professor Sarah De Val and Dr Joaquim Vieira are two of eight projects to receive funding from these proceeds.
New evidence for how our brains handle surprise
Bruno Group News Integrative Neuroscience Publication Research
30 September 2022
A new study from the Bruno Group is challenging our perceptions of how the different regions of the cerebral cortex function. A group of ‘quiet’ cells in the somatosensory cortex that rarely respond to touch have been found to react mainly to surprising circumstances. The results suggest their function is not necessarily driven by touch, but may indicate an important and previously unidentified role across all the major cortices.
Professor Dame Sue Black to deliver 2022 Christmas Lectures
EDI News General Research
26 September 2022
In the 2022 Christmas Lectures from the Royal Institution, DPAG's Visiting Professor of Forensic Anatomy Dame Sue Black will share secrets of forensic science.
Researchers describe how cancer cells can defend themselves from the consequences of certain genetic defects
Cell Physiology Publication Research
16 September 2022
Swietach Group scientists have identified a rescue mechanism that allows cancers to overcome the consequences of inactivating mutations in critically important genes.
Randy Bruno and Scott Waddell receive Wellcome Discovery Awards
Awards and Honours CNCB Integrative Neuroscience Research
18 July 2022
Congratulations are in order for Professors Randy Bruno and Scott Waddell who have each been awarded a prestigious Wellcome Trust Discovery Award to significantly enhance our understanding of higher cognitive functions.
Researchers discover novel form of adaptation in the auditory system
Integrative Neuroscience Publication Research
21 June 2022
DPAG’s auditory neuroscience researchers have found that the auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to remove reverberation.
Collaborative team driven by DPAG and Chemistry awarded RSC Horizon Prize
Awards and Honours Cell Physiology Research
7 June 2022
The Molecular Flow Sensor Team, with collaborating members principally from DPAG’s Robbins and Talbot groups and the Department of Chemistry, has been named the winner of the Royal Society of Chemistry’s (RSC) Analytical Division Horizon Prize for the development of a new technology for measuring lung function.
Oxford Parkinson’s Disease Centre awarded £3.8 million to reveal the role of calcium in Parkinson’s
Awards and Honours Cragg Group News OPDC News Research Wade-Martins Group News
29 April 2022
A collaborative research team led by the Oxford Parkinson’s Disease Centre (OPDC) has been awarded a £3.8 million Wellcome Trust Collaborative Award to study the function of calcium in dopamine neurons, and how this is plays a role in Parkinson’s. Their research will help explain how and why dopamine neurons are vulnerable in the disease and look at how they may be preserved.
The effect of nuclear pH on cardiac gene expression
Cardiac Theme Cell Physiology Postdoctoral Publication Research
13 April 2022
Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.
A role of sleep in tinnitus identified for the first time
Integrative Neuroscience Publication Research
8 April 2022
Phantom percepts, such as subjective tinnitus, are driven by fundamental changes in spontaneous brain activity. Sleep is a natural example of major shifts in spontaneous brain activity and perceptual state, suggesting an interaction between sleep and tinnitus that has so far been little considered. In a new collaborative review article from DPAG’s auditory and sleep neuroscientists, tinnitus and sleep research is brought together for the first time, and, in conclusion, they propose a fundamental relationship between natural brain dynamics and the expression and pathogenesis of tinnitus.
An unexpected role for the cell’s largest membrane network
Cell Physiology Klemm Group News Publication Research
7 April 2022
A new Klemm Lab-led paper has uncovered a new mechanism involving the endoplasmic reticulum that is critical to the organisation and position of the microtubule (MT) cytoskeleton, which ultimately dictates the shape and function of our body’s cells.
Little understood brain region linked to how we perceive pain
Integrative Neuroscience Publication Research Vyazovskiy Group News
28 March 2022
A new DPAG-led review paper, published in the journal Brain, has shown that a poorly understood region of the brain called the claustrum may play an important role in how we experience pain.
New insights into little understood regulator of blood sugar levels
Cell Physiology Postdoctoral Publication Research
25 March 2022
A new Novo Nordisk project paper has uncovered the role of ACC1 enzyme in the regulation of glucagon secretion for the first time. This raises the prospect of a potential new therapeutic target in the context of type 2 diabetes and metabolic disorders characterised by hyperglycaemia.
Armin Lak set to reveal neural code for learning under uncertainty with ERC Starting Grant
Awards and Honours Integrative Neuroscience Research
18 March 2022
Congratulations are in order for Sir Henry Dale Fellow Dr Armin Lak who has been awarded a Starting Grant from the European Research Council. His funded project will investigate the neural circuits for learning under perceptual uncertainty.
New gene target identified to prevent tumour growth under acidity
Cell Physiology Postdoctoral Publication Research
11 March 2022
A new paper led by Dr Johanna Michl and Professor Pawel Swietach from DPAG’s Swietach Group has identified a new gene that allows cancer cells to survive in the typically acidic microenvironment of a malignant tumour. They have discovered drugs that inhibit the gene in other medical conditions also selectively kill cancer cells at acidic pH, without damaging healthy tissue. This defines a novel strategy for targeting acidic tumour regions.
New insights into the role of dopamine in reinforcement learning
Cragg Group News OPDC News Postdoctoral Publication Research
11 March 2022
A new study from Dr Yanfeng Zhang has uncovered the first evidence that dopamine-dependent long-term potentiation is also gated by the pause of striatal cholinergic interneurons and the depolarisation of the striatal spiny projection neurons. This discovery overturns previous ideas that the phasic dopamine release is the only factor gate corticostriatal synaptic plasticity, thus changing our understanding of dopamine functions in reinforcement learning.
New insights into how the brain rewires after early sensory loss
Integrative Neuroscience Molnar Group News Publication Research
18 February 2022
A new paper from the Molnár Group has shed light on substantial rewiring of corticothalamic connections that is triggered by early sensory loss during development. The study has identified a new mechanism that significantly rearranges the cortico-thalamo-cortical circuits but has not been considered before in patients with sensory loss for potential therapies.
London Marathon to fund De Val and Vieira Lab research as two of eight handpicked BHF projects
De Val Group News Outreach Postdoctoral Research Vieira Group News
14 February 2022
Two projects aimed at tackling heart failure led by Associate Professor Sarah De Val and Dr Joaquim Vieira are to be funded by the 2022 TCS London Marathon with the British Heart Foundation as its Charity of the Year. The BHF’s runners, who are raising £3 million in funding, will include De Val Lab postdoctoral researcher Dr Alice Neal.