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Found 299 matches for
Key exosome subtype in cancer progression identified
Publication Research Wilson Group News
8 March 2023
Collaborative work from DPAG and Oncology researchers has revealed a potential new pathway to block the production of a specific group of exosomes made in the cell’s recycling system that can promote the growth of cancerous tumours.
New blood test from DPAG cardiac researchers could save lives of heart attack victims
Cardiac Theme Herring Group News Publication Research
31 January 2023
Researchers from the Herring group have developed a blood test that measures stress hormone levels after heart attacks. The test – costing just £10 – could ensure patients receive timely life-saving treatment.
Mootaz Salman set to target new treatments for stroke
Awards and Honours OPDC News Research Salman Group News Wade-Martins Group News
25 January 2023
The Chief Scientist Office of the Government of Scotland has awarded a collaborative grant of £298,966 to Dr Mootaz Salman to seek new therapeutic avenues to treat stroke.
New BBSRC grant to further our insights into how the cortex controls sleep
Awards and Honours Integrative Neuroscience Molnar Group News Research Vyazovskiy Group News
15 December 2022
Professor of Sleep Physiology Vladyslav Vyazovskiy and Professor of Developmental Neuroscience Zoltán Molnár have been awarded a Project Grant from the Biotechnology and Biological Sciences Research Council (BBSRC) for “Brain mechanisms of sleep: top-down or bottom-up?”
Raised intracellular chloride levels underlie the effects of tiredness in cortex
Publication Research Vyazovskiy Group News
13 December 2022
A new study, co-authored by Professor Vladyslav Vyazovskiy, published in Nature Neuroscience, has revealed that intracellular chloride levels within cortical pyramidal neurons reflect sleep–wake history.
Key cause of type 2 diabetes uncovered
Ashcroft Group News Postdoctoral Publication Research
14 November 2022
Research led by Dr Elizabeth Haythorne and Professor Frances Ashcroft reveals high blood glucose reprograms the metabolism of pancreatic beta-cells in diabetes. They have discovered that glucose metabolites, rather than glucose itself, are key to the progression of type 2 diabetes. Glucose metabolites damage pancreatic beta-cell function, so they are unable to release enough of the hormone insulin. Reducing the rate at which glucose is metabolised, and these glucose metabolites build up, can prevent the effects of hyperglycaemia.
New study shows clinical symptoms for Alzheimer’s can be predicted in preclinical models
OPDC News Publication Research Wade-Martins Group News
10 November 2022
Establishing preclinical models of Alzheimer’s that reflect in-life clinical symptoms of each individual is a critically important goal, yet so far it has not been fully realised. A new collaborative study from the University of Oxford has demonstrated that clinical vulnerability to an abnormally abundant protein in Alzheimer’s brain is in fact reflected in individual patient induced pluripotent stem cell-derived cortical neurons.
Updating the circuit maps of the sympathetic neural network
Domingos Group News Publication Research
3 November 2022
A new review from Professor Ana Domingos’ lab and colleagues offers a fresh modern viewpoint on sympathetic neurons and their relation to immune cells and obesity.
New Pfizer grant paves the way to a better understanding of how body fat is controlled
Awards and Honours Domingos Group News EDI News Research
1 November 2022
Professor Ana Domingos has been awarded a highly competitive independent research grant from Pfizer to discover ‘the role of Sympathetic-associated Perineurial barrier Cells in obesity’.
Collaborative MRC grant paves the way to new therapeutic targets for stress and anxiety disorders
Awards and Honours Integrative Neuroscience Molnar Group News Research
25 October 2022
Dr Armin Lak, Associate Professor Ed Mann and Professor Zoltán Molnár have been awarded a £733K Project Grant from the Medical Research Council on “Orexinergic projections to neocortex: potential role in arousal, stress and anxiety-related disorders”.
New computational technique reveals changes to lung function post COVID-19 infection
Cell Physiology Publication Research
5 October 2022
A collaborative DPAG-led study studied patients at six and twelve months after COVID-19 infection, finding that prior COVID-19 infection was associated with more uneven inflation of the lungs during normal breathing. There was also an association between hospitalisation with COVID-19 and smaller lung volumes, and admission to the intensive care unit (ICU) was associated with an enlarged respiratory dead space.
BHF funded DPAG projects to receive share of £2 million raised by the London Marathon
De Val Group News Outreach Research Vieira Group News
5 October 2022
The British Heart Foundation were charity of the year for the 2022 TCS London Marathon. Around 800 BHF London Marathon runners, including former De Val lab researcher Dr Alice Preston, have raised nearly £2 million, and rising, for BHF-funded science that could lead to improved new treatments for heart failure. Research led by Associate Professor Sarah De Val and Dr Joaquim Vieira are two of eight projects to receive funding from these proceeds.
New evidence for how our brains handle surprise
Bruno Group News Integrative Neuroscience Publication Research
30 September 2022
A new study from the Bruno Group is challenging our perceptions of how the different regions of the cerebral cortex function. A group of ‘quiet’ cells in the somatosensory cortex that rarely respond to touch have been found to react mainly to surprising circumstances. The results suggest their function is not necessarily driven by touch, but may indicate an important and previously unidentified role across all the major cortices.
Professor Dame Sue Black to deliver 2022 Christmas Lectures
EDI News General Research
26 September 2022
In the 2022 Christmas Lectures from the Royal Institution, DPAG's Visiting Professor of Forensic Anatomy Dame Sue Black will share secrets of forensic science.
Researchers describe how cancer cells can defend themselves from the consequences of certain genetic defects
Cell Physiology Publication Research
16 September 2022
Swietach Group scientists have identified a rescue mechanism that allows cancers to overcome the consequences of inactivating mutations in critically important genes.
Randy Bruno and Scott Waddell receive Wellcome Discovery Awards
Awards and Honours CNCB Integrative Neuroscience Research
18 July 2022
Congratulations are in order for Professors Randy Bruno and Scott Waddell who have each been awarded a prestigious Wellcome Trust Discovery Award to significantly enhance our understanding of higher cognitive functions.
Researchers discover novel form of adaptation in the auditory system
Integrative Neuroscience Publication Research
21 June 2022
DPAG’s auditory neuroscience researchers have found that the auditory system adapts to the changing acoustics of reverberant environments by temporally shifting the inhibitory tuning of cortical neurons to remove reverberation.
Collaborative team driven by DPAG and Chemistry awarded RSC Horizon Prize
Awards and Honours Cell Physiology Research
7 June 2022
The Molecular Flow Sensor Team, with collaborating members principally from DPAG’s Robbins and Talbot groups and the Department of Chemistry, has been named the winner of the Royal Society of Chemistry’s (RSC) Analytical Division Horizon Prize for the development of a new technology for measuring lung function.
Oxford Parkinson’s Disease Centre awarded £3.8 million to reveal the role of calcium in Parkinson’s
Awards and Honours Cragg Group News OPDC News Research Wade-Martins Group News
29 April 2022
A collaborative research team led by the Oxford Parkinson’s Disease Centre (OPDC) has been awarded a £3.8 million Wellcome Trust Collaborative Award to study the function of calcium in dopamine neurons, and how this is plays a role in Parkinson’s. Their research will help explain how and why dopamine neurons are vulnerable in the disease and look at how they may be preserved.