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The effect of nuclear pH on cardiac gene expression
Cardiac Theme Cell Physiology Postdoctoral Publication Research
13 April 2022
Research led by Dr Alzbeta Hulikova and Professor Pawel Swietach has, for the first time, described the potential regulation of nuclear acid-base chemistry in neonatal and adult cardiomyocytes, and explained its relevance in the context of heart physiology and pathology.
A role of sleep in tinnitus identified for the first time
Integrative Neuroscience Publication Research
8 April 2022
Phantom percepts, such as subjective tinnitus, are driven by fundamental changes in spontaneous brain activity. Sleep is a natural example of major shifts in spontaneous brain activity and perceptual state, suggesting an interaction between sleep and tinnitus that has so far been little considered. In a new collaborative review article from DPAG’s auditory and sleep neuroscientists, tinnitus and sleep research is brought together for the first time, and, in conclusion, they propose a fundamental relationship between natural brain dynamics and the expression and pathogenesis of tinnitus.
An unexpected role for the cell’s largest membrane network
Cell Physiology Klemm Group News Publication Research
7 April 2022
A new Klemm Lab-led paper has uncovered a new mechanism involving the endoplasmic reticulum that is critical to the organisation and position of the microtubule (MT) cytoskeleton, which ultimately dictates the shape and function of our body’s cells.
Little understood brain region linked to how we perceive pain
Integrative Neuroscience Publication Research Vyazovskiy Group News
28 March 2022
A new DPAG-led review paper, published in the journal Brain, has shown that a poorly understood region of the brain called the claustrum may play an important role in how we experience pain.
New insights into little understood regulator of blood sugar levels
Cell Physiology Postdoctoral Publication Research
25 March 2022
A new Novo Nordisk project paper has uncovered the role of ACC1 enzyme in the regulation of glucagon secretion for the first time. This raises the prospect of a potential new therapeutic target in the context of type 2 diabetes and metabolic disorders characterised by hyperglycaemia.
New gene target identified to prevent tumour growth under acidity
Cell Physiology Postdoctoral Publication Research
11 March 2022
A new paper led by Dr Johanna Michl and Professor Pawel Swietach from DPAG’s Swietach Group has identified a new gene that allows cancer cells to survive in the typically acidic microenvironment of a malignant tumour. They have discovered drugs that inhibit the gene in other medical conditions also selectively kill cancer cells at acidic pH, without damaging healthy tissue. This defines a novel strategy for targeting acidic tumour regions.
New insights into the role of dopamine in reinforcement learning
Cragg Group News OPDC News Postdoctoral Publication Research
11 March 2022
A new study from Dr Yanfeng Zhang has uncovered the first evidence that dopamine-dependent long-term potentiation is also gated by the pause of striatal cholinergic interneurons and the depolarisation of the striatal spiny projection neurons. This discovery overturns previous ideas that the phasic dopamine release is the only factor gate corticostriatal synaptic plasticity, thus changing our understanding of dopamine functions in reinforcement learning.
New insights into how the brain rewires after early sensory loss
Integrative Neuroscience Molnar Group News Publication Research
18 February 2022
A new paper from the Molnár Group has shed light on substantial rewiring of corticothalamic connections that is triggered by early sensory loss during development. The study has identified a new mechanism that significantly rearranges the cortico-thalamo-cortical circuits but has not been considered before in patients with sensory loss for potential therapies.
New book expands the horizons of brain research
Integrative Neuroscience Molnar Group News Publication
17 January 2022
A pioneering book from Professor Zoltán Molnár and Yale Professors Tamas Horvath and Joy Hirsch to be released on 1 February 2022 addresses the fundamental relationship between the body, brain and behaviour.
Switch with a spring: a new model for sleep regulation
Publication Research Vyazovskiy Group News
16 December 2021
New collaborative research led by the Vyazovskiy Group has shed new light on the role of the hypothalamus in the transition between sleep and wake states.
Oxford-led research maps milestone stage of human development for the first time
Postdoctoral Publication Research Srinivas Group news
18 November 2021
Scientists have shed light on an important stage of early embryonic development that has never been fully mapped out in humans before.
Drug could help diabetic hearts recover after a heart attack
Cardiac Theme Heather Group News Publication Research
20 October 2021
New research led by Associate Professor Lisa Heather has found that a drug known as molidustat, currently in clinical trials for another condition, could reduce risk of heart failure after heart attacks.
Blood bank storage can reduce ability of transfusions to treat anaemia
Cell Physiology Publication Research
13 September 2021
New research from the Swietach Group in collaboration with NHS Blood and Transplant has demonstrated that the process of storing blood in blood banks can negatively impact the function of red blood cells and consequently may reduce the effectiveness of blood transfusions, a treatment commonly used to combat anaemia.
Overlapping second messengers increase dynamic control of physiological responses
Cell Physiology Publication Research
3 September 2021
New research from the Parekh and Zaccolo groups reveals that a prototypical anchoring protein, known to be responsible for regulating several important physiological processes, also orchestrates the formation of two important universal second messengers.
Feeling tired? Here’s how the brain’s ‘hourglass’ controls your need for sleep – new research
Publication Research Vyazovskiy Group News
24 August 2021
New article on The Conversation website written by Dr Lukas Krone, Associate Professor Vladyslav Vyazovskiy and Professor Zoltán Molnár.
Scientists Decipher How NeuroImmune Interactions Burn Deep Fat
Domingos Group News Publication Research
20 August 2021
A pioneering collaborative mouse study from an international team of researchers including DPAG's Associate Professor Ana Domingos published in Nature offers new therapeutic avenues for reducing visceral fat stores, which have been associated with cardiovascular disease and multiple types of cancer.
Continued ethical animal research needed to advance treatment of brain disease, researchers argue
Publication Research Vyazovskiy Group News
5 August 2021
More research is needed to improve the treatment of brain diseases such as depression, Alzheimer’s or ADHD. A widely held view within the scientific community is that this cannot be done without ethically conducted animal research. A team of seventy international neuroscientists, including DPAG’s Associate Professor Vladyslav Vyazovskiy, have now published a warning that animal research is under pressure, which endangers the further development of treatments.
Cortex may regulate the need for sleep
Integrative Neuroscience Molnar Group News Publication Research Vyazovskiy Group News
2 August 2021
Why we sleep, and the processes behind sleep, are amongst the most interesting questions in modern neuroscience. Researchers at the University of Oxford, including DPAG's Molnár and Vyazovskiy group scientists, have now uncovered a new target for sleep investigations within the mammalian brain – the cerebral cortex. The paper, first authored by Dr Lukas Krone, was published today in Nature Neuroscience.
Reducing fat in the diabetic heart could improve recovery from heart attack
Heather Group News Publication Research
29 July 2021
New research from the Heather Group has shown that in type 2 diabetes an overload of lipids reduces the heart’s ability to generate energy during a heart attack, decreasing chances of recovery.
The brain’s one-sided teaching signals
Integrative Neuroscience Publication Research
16 July 2021
A new study by the Lak group reveals a novel facet of dopamine signalling during visual decision making.