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New light shed on what controls our motivated actions
Cragg Group News Publication Research
20 September 2019
The release of dopamine in the brain plays a key role in determining how we respond when we perceive a potential reward or benefit. But so far little has been understood about the mechanism behind this. A new collaborative paper from Prof Stephanie Cragg's Group and Prof Ed Mann published in Nature Communications has uncovered a dominant regulator of the dynamics of dopamine output.
Zoltán Molnár evaluates latest research into human cerebral cortex development
Integrative Neuroscience Molnar Group News Publication Research
22 August 2019
Professor Zoltán Molnár has edited a special issue of Journal of Anatomy with Dr Gavin Clowry from the University of Newcastle on Human Brain Development. This issue contains 15 original articles, an overview and an editorial on Human Brain Development.
Understanding the role of little known gene in regulating our metabolism
Cell Physiology Publication Research
24 July 2019
Thousands of genes are involved in the regulation of our day-to-day metabolism and relatively little is understood about their function. One key protein, an ABC Transporter called ABCC5, has recently been predicted to be a susceptibility gene for Type 2 diabetes. In a new study selected as Editor's Choice in Obesity, Associate Professor Heidi de Wet has confirmed ABCC5's role in energy metabolism and identified the mechanism behind its metabolic impact for the first time.
Potential strategy identified to improve blood vessel growth after heart attack
De Val Group News Publication Research
22 July 2019
A collaborative paper from the De Val and Smart Groups has established multiple regulatory pathways responsible for the formation of blood vessels in the developing heart. In doing so they have identified a crucial pathway that is repressed in the adult heart after injury, which may hold the key to a new and improved strategy for repair.
Emma Bardsley and David Paterson awarded Hypertension's top paper for 2018
Awards and Honours EDI News Head of Department's News Publication
17 July 2019
Congratulations are in order for Dr Emma Bardsley and Professor David Paterson, who have been awarded top paper for 2018 by the journal Hypertension.
New study discovers the impact of environment on sleep patterns in wild primates
Publication Research Vyazovskiy Group News
15 July 2019
Associate Professor Vladyslav Vyazovskiy has co-authored a paper based on a pioneering sleep study led by Oxford Brookes researchers. Their research into a nocturnal primate performed in the wild is the first of its kind and could enhance our understanding of human sleep.
New approach to reducing damage after a heart attack
Cardiac Theme Herring Group News Publication Research
12 July 2019
During the emergency procedure used to reopen the blocked artery causing a heart attack, smaller "micro" blood vessels can remain constricted causing significant damage. A new study led by Associate Professor Neil Herring and published in the European Heart Journal has established a key cause behind this constriction and identified a potential therapeutic target to block the mechanism behind it.
Critical role demonstrated for the auditory cortex in adapting to hearing loss
Integrative Neuroscience Publication Research
12 July 2019
A collaborative King Group study published today in Nature Communications enhances our understanding of how our brains learn to adapt to abnormal sensory changes such as hearing loss. Their results could inform the future development of devices that restore hearing or other sensory impairments.
New insights into Cajal's interactions with Sherrington and the Croonian Lecture
Integrative Neuroscience Molnar Group News Publication
20 June 2019
Professor Zoltán Molnár has co-written an insightful paper into the story of preeminent neuroscientist Santiago Ramón y Cajal's delivery of the Croonian Lecture over a century ago and his interactions with Sir Charles Sherrington, our former Waynflete Professor of Physiology.
Drinking alcohol at conception shown to cause harm
Postdoctoral Publication Research
13 June 2019
Research carried out by Postdoctoral Research Scientist Jacinta Kalisch-Smith during her PhD, now published in Development, reveals key insights into the effects of alcohol in the very early stages of pregnancy, a stage during which a mother is unlikely to know she is pregnant.
Key insights into the underlying mechanisms behind Type 2 diabetes
Ashcroft Group News Postdoctoral Publication Research
12 June 2019
Research led by Postdoctoral Research Scientist Dr Elizabeth Haythorne and published in Nature Communications sheds light on a vicious cycle that causes specialised cells to fail in their function to maintain healthy bloody sugar levels.
Critical link revealed between iron deficiency and a serious cardiovascular condition
Cardiac Theme Lakhal-Littleton Group News Publication Research
3 June 2019
A new discovery from the Lakhal-Littleton Group on how iron deficiency affects the vasculature of the lung could hold the key to improving treatment of pulmonary arterial hypertension.
New research advances our understanding of vascular development
Postdoctoral Publication Research Stone Group News
23 May 2019
Dr Oliver Stone’s paper “Paraxial mesoderm is the major source of lymphatic endothelium” published in Developmental Cell reveals the earliest known step in the formation of the lymphatic vasculature.
New guidelines available for controlling pH in cell culture systems could improve reproducibility in numerous experiments
Cell Physiology Postdoctoral Publication
9 May 2019
Preparing media for tissue culture, but not sure how to get it to the right pH? Worried about pH changes during your incubations? DPAG Group publishes recommendations for best practice in controlling and managing pH under culture conditions.
Rhys Evans co-authors bestselling guide to human metabolism and metabolic regulation
Publication Research
9 May 2019
The revised and updated "Human Metabolism: A Regulatory Perspective" offers a new and integrated review of metabolism and metabolic regulation, where difficult concepts are explained in clear and concise terms to provide an accessible and essential guide to the topic.
New way to target and treat the leading genetic contributor to Parkinson's
OPDC News Publication Research Wade-Martins Group News
2 May 2019
The Wade-Martins Group has identified how the dysfunction of a key protein, LRRK2, causes the neurons affected in Parkinson's to lose their ability to effectively clear out cell components that have been damaged. This discovery has enabled the team to find a new way to target and correct this issue, paving the way for a potential new clinical treatment.
OPDC research sheds light on the greatest known genetic contributor to Parkinson's
OPDC News Postdoctoral Publication Research Wade-Martins Group News
11 April 2019
A new study from OPDC Career Development Fellow Natalie Connor-Robson investigates how mutations in the gene LRRK2, which are known to cause Parkinson’s, affect normal cell function.
New insight uncovered into one of the most important features of hearing
Integrative Neuroscience Publication Research
4 April 2019
Dr Kerry Walker and her team help us to better understand how we perceive pitch, a feature of hearing critical to recognising communication through sound, such as speech and music.
Sleep and ageing: two sides of one coin?
CNCB Publication Research
25 March 2019
The Miesenböck Group have discovered a brain process common to sleep and ageing in research that could pave the way for new treatments for insomnia.
Striking new evidence into the cause of the most common type of birth defect in babies
Cardiac Theme Publication Research
1 March 2019
Dr Duncan Sparrow has published a new paper in collaboration with the Victor Chang Cardiac Research Institute entitled "Gene-environment interaction impacts on heart development and embryo survival."