Publications Archive

PUBLICATIONS BY DATE

2023 2022 2021 2020 2019 2018 2017 2016 2015 2014 

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2003 2002 2001 2000 1999 1998 1997 1996 1995 1994 

1993 1992 1991 1990 1989 1988 1987 1986

Refereed reviews

Book chapters

Publications for 2023

Paterson DJ, Shivkumar K.  Bioelectronics for neurocardiology: diagnosis and therapeutics.  European Heart Journal (9 November 2023) doi.org/10.1093/euroheartj/ehad624 [Abstract/Full Text] 

Li N, Edel M, Liu K, Denning C, Betts J, Neely OC, Li D, Paterson DJ.  Human induced pluripotent stem cell-derived cardiac myocytes and sympathetic neurons in disease modelling, Philosophical Transactions of the Royal Society B (1 May 2023) doi:org/10.1098/rstb.2022.0173 [Abstract/Full Text]

Tomek J, Herring N, Paterson DJ.  Sympathetic control of the heart.   Primer on the Autonomic Nervous System, Academic Press pp 185-191 (2023).  doi.org/10.1016/B978-0-323-85492-4.00042-9  [Abstract/Full Text]

Robertson C, Paterson DJ, Herring N.  Primer on the Autonomic Nervous System, Academic Press pp 81-87 (2023).  doi.org/10.1016/B978-0-323-85492-4.00124-1  [Abstract/Full Text]

Publications for 2022

Davis H, Liu K, Li N,Li D, Paterson DJ.  Healthy cardiac myocytes can decrease sympathetic hyperexcitability in the early stages of hypertension.  Frontiers in Synaptic Neuroscience 4 August 2022.  doi: 10.3389/fnsyn.2022.949150.  [Abstract/Full Text]

Davis H, Paterson DJ, Herring N.  Post-ganglionic sympathetic neurons can directly sense raised extracellular Na+ via SCN7a/Nax.  Front Physiol 13:931094 2022 doi: 10.3389/fphys.2022.931094. [Abstract/Full Text]            

Li, D, Lui K, Davis H, Robertson, Neely OC, Tarafdar A, Li N, Lefkimmiatis K, Zaccolo M, Paterson DJ.  Abnormal Cyclic Nucleotide Signalling at the Outer Mitochondrial Membrane in Sympathetic Neurons During the Early Stages of Hypertension.  Hypertension 2022. doi: 10.1161/hypertensionaha.121.18882.  [Abstract/Full Text]

Neely OC, Domingos AI, Paterson DJ.  Macrophages Can Drive Sympathetic Excitability in the Early Stages of Hypertension. Frontiers Cardiovasc Med 27 January 2022.  doi: 10.3389/fcvm.2021.807904. [Abstract/Full Text]

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Publications for 2021

Gongxin Wang, Chieh-Ju Lu, Andrew W Trafford, Xiaohui Tian, Hannali M Flores, Piotr Maj, Kevin Zhang, Yanhong Niu, Luxi Wang, Yimei Du, Xinying Ji, Yanfang Xu, Lin Wu, Dan Li, Neil Herring, David Paterson, Christopher L-H Huang, Henggui Zhang, Ming Lei, Guoliang Hao.  Electrophysiological and Proarrhythmic Effects of Hydoxychloroquine Challenge in Guinea-Pig Hearts.  ACS Pharmacology & Translational Science.  Aug 30,2021. 
doi.org/10.1021/acsptsci.1c00166. [Abstract/Full Text]

Dhani Dharmaprani, Christopher Bradley, Martin Hayward, David Paterson, Peter Taggart, Evan Jenkins, Jing Xian Quah, Anandaroop Lahiri, Kathryn Tiver, Lewis Mitchell, Richard H Clayton, Martyn P Nash, Anand N Ganesan. B-YIA2-03 A Governing Equation to Explain the Number of Wavelets and Rotors Observed in Human Ventricular Fibrilation.  Hearth Rhythm Vol 18 Issue 8 Supplement, Page S50. Aug 01 2021.  doi.org/10.1016/j.hrthm.2021.06.145. [Abstract/ Full Text]

Herring N, Paterson DJ.  The Heart's Little Brain: Shedding New Light and CLARITY on the "Black Box".  Circulation Research 2021;128: 1297-1299 doi.org/10.1161/CIRCRESAHA.121.319148  [Abstract/Full Text]

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publications for 2020

Davis H, Herring N, Paterson DJ. Downregulation of M Current is Coupled to Membrane Excitability in Sympathetic Neurons Before the Onset of Hypertension. (2020) Hypertension Dec 76 (6), 1915-1923. doi.10.1161/HYPERTENSIONAHA.120.15922  [Abstract/Full Text]

Burton RB, Tomek J, Ambrosi CM, Larsen HE, Sharkey AR, Capel RA, Corbett AD, Bilton S, Klimas A, Stephens G, Cremer M, Bose SJ, Li D, Gallone G, Herring N, Mann EO, Kumar A, Kramer H, Entcheva E, Paterson DJ, Bub G.  Optical Interrogation of Sympathetic Neuronal Effects on Macroscopic Cardiomyocyte Network Dynamics.  iScience. 2020 Jul 24;23(7):101334.  doi:10.1016/j.isci.2020.101334   [Epub 2020 Jul 1]

Sverrisdottir YB, Martin SC, Hadjipavlou G, Kent AR, Paterson DJ, Fitzgerald JJ, Green, AL (2020).  Human Dorsal Root Ganglion Stimulation Reduces Sympathetic Outflow and Long-Term Blood Pressure.  JACC: Basic to Translation Science. doi .org/10.1016/j.jacbts.2020.07.010 [Abstract/Full Text]

Green AL, Paterson DJ (2020).  Using Deep Brain Stimulation to Unravel the Mysteries of Cardiorespiratory Control.  Comprehensive Physiology,10, 1085-1104.  2020 July, Issue 3.  doi: org/10.1002/cphy.c190039 [Abstract/Full Text]

Bardsley EN, Paterson DJ. (2020) Neurocardiac regulation: from cardiac mechanisms to novel therapeutic approaches. J Physiol  2020 Jul;598(14):2957-2976, doi: 10.1113/JP276962 [Abstract/Full Text]

Kalla M, Hao G, Tapoulal N, Tomek J, Liu K, Woodward L; Oxford Acute Myocardial Infarction (OxAMI) Study, Dall'Armellina E, Banning AP, Choudhury RP, Neubauer S, Kharbanda RK, Channon KM, Ajijola OA, Shivkumar K, Paterson DJ, Herring N. The Cardiac Sympathetic Co-transmitter Neuropeptide Y is a Pro-arrhythmic following ST-evelation Myocardial Infarction despite Beta-blockade. Eur Heart J. 2020 June 14;41(23):2168-2179. doi: 10.1093/eurheartj/ehz852. [Abstract/Full Text]

Winbo A, Paterson DJ (2020). The Brain-Heart Connection in Sympathetically Triggered Inherited Arrhythmia Syndromes. Heart Lung Circ. April 2020, Vol 29, Issue 4, Pages 529-537 doi: 10.1016/j.hlc.2019.11.002. [Abstract/Full Text]

Ajijola OA, Chatterjee NA, Gonzales MJ, Gornbein J, Liu K, Li D, Paterson DJ, Shivkumar K, Singh JP, Herring N. Coronary Sinus Neuropeptide Y Levels and Adverse Outcomes in Patients with Stable Chronic Heart Failure, JAMA Cardiol. 2020 Mar 1;5(3):318-325. doi: 10.1001/jamacardio.2019.4717. [Absract/Full Text]

Bardsley EN, Neely OC, Paterson DJ (2020). Angiotensin Peptide Synthesis and Cyclic Nucleotide Modulation in Sympathetic Stellate Ganglia. J Mol Cell Cardiol. 2020 Jan 10. pii: S0022-2828(19)30385-2. doi: 10.1016/j.yjmcc.2019.11.157. [Abstract/Full Text]

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PUBLICATIONS FOR 2019

Calamera G, Li D, Ulsund AH, Kim JJ, Neely OC, Moltzau LR, Bjørnerem M, Paterson D, Kim C, Levy FO, Andressen KW (2019) FRET-based Cyclic GMP Biosensors Measure Low cGMP Concentrations in Cariomyocytes and Neurons. Commun Biol. 2019 Oct 29;2:394. doi: 10.1038/s42003-019-0641-x. eCollection 2019 [Abstract/Full Text]

Richards MA, Simon JN, Ma R, Loonat AA, Crabtree MJ, Paterson DJ, Fahlman RP, Casadei B, Fliegel L, Swietach P (2019) Nitric Oxide Modulates Cardiomyocyte pH Control through a Biphasic effect on Sodium/Hydrogen Exchanger-1. Cardiovasc Res Nov 2019 pii: cvz311 doi:
10.1093/cvr/cvz311 [Abstract/Full Text]

Ashton JL, Trew ML, LeGrice IJ, Paterson DJ, Gillis AM, Smaill BH (2019) Shift of Leading Pacemaker Site during Reflex Vagal Stimulation and Altered Electrical Source-to-sink Balance. J Physiol 2019 Jul:597(13) doi: 10.1113/JP276876 [Abstract/Full Text]

Herring N, Kalla M, Paterson DJ (2019) The Autonomic Nervous System and Cardiac Arrhythmias: Current Concepts and Emerging Therapies. Nat Rev Cardiol 2019 June 13 doi: 10.1038/s41569-019-0221-2 [Abstract/Full Text]

Tomek J, Hao G, Tomková M, Lewis A, Carr C, Paterson DJ, Rodriguez B, Bub G, Herring (2019) β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and Computational Investigation of Arrhythmogenesis. Front Physiol. doi: 10.3389/fphys.2019.00350. [Abstract/Full Text]

Li D. and Paterson DJ., (2019) Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability. Semin Cell Dev Biol. doi: 10.1016/j.semcdb.2019.01.010 [Abstract/Full Text].

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PUBLICATIONS FOR 2018

Davis H, Bardsley EN, Paterson DJ.  (2018) Transcriptional profiling of stellate ganglia from normotensive and spontaneously hypertensive rat strains. Sci Data. doi: 10.1038/sdata.2018.123. [Abstract/Full Text]

Bardsley EN, Davis H, Ajijola OA, Buckler KJ, Ardell JL, Shivkumar K, Paterson DJ.  (2018) RNA Sequencing Reveals Novel Transcripts from Sympathetic Stellate Ganglia during Cardiac Sympathetic Hyperactivity.  Sci Rep.  doi: 10.1038/s41598-018-26651-7.  [Abstract/Full Text]

Yavari A, Bellahcene M, Bucchi A, Sirenko S, Pinter K, Herring N, Jung JJ, Tarasov KV, Sharpe EJ, Wolfien M, Czibik G, Steeples V, Ghaffari S, Nguyen C, Stockenhuber A, Clair JRS, Rimmbach C, Okamoto Y, Yang D, Wang M, Ziman BD, Moen JM, Riordon DR, Ramirez C, Paina M, Lee J, Zhang J, Ahmet I, Matt MG, Tarasova YS, Baban D, Sahgal N, Lockstone H, Puliyadi R, de Bono J, Siggs OM, Gomes J, Muskett H, Maguire ML, Beglov Y, Kelly M, Dos Santos PPN, Bright NJ, Woods A, Gehmlich K, Isackson H, Douglas G, Ferguson DJP, Schneider JE, Tinker A, Wolkenhauer O, Channon KM, Cornall RJ, Sternick EB, Paterson DJ, Redwood CS, Carling D, Proenza C, David R, Baruscotti M, DiFrancesco D, Lakatta EG, Watkins H, Ashrafian H. (2017) Mammalian γ2 AMPK regulates intrinsic heart rate. Nat Commun. 2;8(1):1258. [Full text]

Shanks J, Herring N, Johnson E, Liu K, Li D, Paterson DJ. (2017) Overexpression of Sarcoendoplasmic Reticulum Calcium ATPase 2a Promotes Cardiac Sympathetic Neurotransmission via Abnormal Endoplasmic Reticulum and Mitochondria Ca2+ Regulation. Hypertension. 69(4):625-632 [Epub ahead of print]

Wang Y, Lin WK, Crawford W, Ni H, Bolton EL, Khan H, Shanks J, Bub G, Wang X, Paterson DJ, Zhang H, Galione A, Ebert SN, Terrar DA, Lei M.(2017) Optogenetic Control of Heart Rhythm by Selective Stimulation of Cardiomyocytes Derived from Pnmt+ Cells in Murine Heart. Sci Rep. 7:40687 [Epub ahead of print]

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PUBLICATIONS FOR 2016

Larsen HE, Lefkimmiatis K, Paterson DJ. (2016) Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease. Sci Rep. 6:38898 [Epub ahead of print]

Paterson DJ. (2016) Challenges, Opportunities and the Future of Physiological Publications in the Hype Cycle. Physiology (Bethesda). 31(6):386-387 [Epub ahead of print]

Bardsley EN, Larsen HE, Paterson DJ. (2016) Impaired cAMP-cGMP Cross-Talk During Cardiac Sympathetic Dysautonomia. Channels (Austin) Nov 11:1-3 [Epub ahead of print]  

Larsen HE, Bardsley EN, Lefkimmiatis K, Paterson DJ. (2016) Dysregulation of Neuronal Ca2+ Channel Linked to Heightened Sympathetic Phenotype in Prohypertensive States. J Neurosci. 36(33):8562-8573 [Epub ahead of print] 

Kalla M, Herring N, Paterson DJ. (2016) Cardiac sympatho-vagal balance and ventricular arrhythmia. Auton Neurosci. 199:29-37 [Epub ahead of print]

Pijacka W, McBryde FD, Marvar PJ, Lincevicius GS, Abdala AP, Woodward L, Li D, Paterson DJ, Paton JF. (2016) Carotid sinus denervation (CSD) ameliorates renovascular hypertension in adult Wistar rats. J Physiol. 594(21):6255-6266 [Epub ahead of print]

Buttgereit J, Shanks J, Li D, Hao G, Athwal A, Langenickel TH, Wright H, da Costa Goncalves AC, Monti J, Plehm R, Popova E, Qadri F, Lapidus I, Ryan B, Ozcelik C, Paterson DJ, Bader M, Herring N. (2016) C-type natriuretic peptide and NPR-B signalling inhibits cardiac sympathetic neurotransmission and autonomic function. Cardiovasc Res. [Epub ahead of print]

Habecker BA, Anderson ME, Birren SJ, Fukuda K, Herring N, Hoover DB, Kanazawa H, Paterson DJ, Ripplinger CM (2016) Development, cellular and molecular adaptations to heart disease. Molecular and cellular neurocardiology. J Physiol. 594(14):3853-3875 [Full text]

Paterson DJ. (2016) Passing the baton. J Physiol. 594(14):3853-75. [Editorial]

Li D, Paterson DJ. (2016) Cyclic nucleotide regulation of cardiac sympatho-vagal responsiveness. J Physiol. 594(14):3993-4008. [Epub ahead of print].  

Kalla M, Chotalia M, Coughlan C, Hao G, Crabtree MJ, Tomek J, Bub G, Paterson DJ, Herring N (2016). Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide. J Physiol.594(14):3981-92. [Epub ahead of print]

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PUBLICATIONS FOR 2015

Varghese A, Spindler AJ, Paterson D, Noble D. (2015) Rate-dependent activation failure in isolated cardiac cells and tissue due to Na+ channel block. Am J Physiol Heart Circ Physiol. 309(10):H1753-63

Paterson DJ & Paton JF. (2015). Insights gleaned from pharmaco-genetic dissection and modelling of cardio-respiratory neural networks. J Physiol. 593(14):3031. [Abstract/Full Text]

Capel RA, Herring N, Kalla M, Yavari A, Mirams GR, Douglas G, Bub G, Channon K, Paterson DJ, Terrar DA, Burton RB. (2015). Hydroxychloroquine reduces heart rate by modulating the hyperpolarization-activated current If: Novel electrophysiological insights and therapeutic potential. Heart Rhythm. 12(10):2186-94 [Abstract/Full Text]

Bear L.R., Chang, L.K., Le Grice, I.J., Sands, G.B., Lever, N.A., Paterson, D.J.P & Smaill, B.H. (2015). The Forward Problem of Electrocardiography: Is it Solved? Circ Arrhythm Electrophysiol. 8(3):677-84 [Editorial]

Lu C-J, Hao, G. Nikiforova, N. Larsen, H.E., Liu, K., Cabtree, M.J., Li, D., Herring, H., & Paterson, D.J. (2015). CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension. Hypertension 65(6):1288-97 [Abstract/Full Text]

Li, D, Lu, C-J, Hao, G., Wright, H. Woodward, L, Liu, K., Vergari, E., Surdo, N.C., Herring, N., Zaccolo, M., & Paterson, D.J. (2015). Efficacy of B type natriuretic peptide is coupled to phosphodiesterase 2A in cardiac sympathetic neurons. Hypertension 66(1):190-8 [Abstract/Full Text] [Editorial]

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PUBLICATIONS FOR 2014

Kazbanov IV, Clayton RH, Nash MP, Bradley CP, Paterson DJ, Hayward MP, Taggart P, Panfilov AV (2014). Effect of global cardiac ischemia on human ventricular fibrillation: insights from a multi-scale mechanistic model of the human heart. PLoS Comput Biol. 10(11):e1003891 [Abstract/Full Text].

Sverrisdóttir YB, Green AL, Aziz TZ, Bahuri NF, Hyam J, Basnayake SD, Paterson DJ (2014) Differentiated Baroreflex Modulation of Sympathetic Nerve Activity During Deep Brain Stimulation in Humans Hypertension 63(5):1000-10[Abstract/Full Text].

Paterson DJ (2014) Defining the neuro-circuitry of exercise hyperpnoea. J. Physiol. 592(3):433-444 [Abstract/Full Text].

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PUBLICATIONS FOR 2013

Shanks, J. Manou-Stathopoulou, S., Lu, C-J., Li, D., Paterson, DJ & Herring N (2013). Cardiac sympathetic dysfunction in the pre-hypertensive spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 305(7):H980-H986 [Abstract/Full Text].

Shanks, J. Mane, S., Ryan, R. & Paterson DJ. (2013) Ganglion-specific impairment of the norepinephrine transporter in the hypertensive rat. Hypertension 61(1):187-193 [Abstract/Full Text].

Li D, Nikiforova, N., Lu, C-J. Wannop, K., McMenamin, M., Lee CW, Buckler K, Paterson DJ. (2013). Targeted neuronal nitric oxide synthase transgene delivery into stellate neurons reverses impaired intracellular calcium transients in prehypertensive rats. Hypertension 61(1):202-207 [Abstract/Full Text].

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PUBLICATIONS FOR 2012

Herring N & Paterson DJ. (2012) Adaption and Responses: Myocardial Innervations and Neural Control. MuscleFundamental Biology and Mechanisms of Disease. 1(20):275-284.

Smith NP, McCulloch AD, Paterson DJ (2012). What can modelling provide to cardiac physiology? J. Physiol. 590(18):4401-2 [Full text].

Herring, N., Cranley, J., Lokale, M.N., Li, D., Shanks, J., Alston, E.N., Girard, B.M., Carter, E., Parsons, R.L., Habecker, B.A. and Paterson, D.J. (2012) The cardiac sympathetic co-transmitter galanin reduces acetylcholine release and vagal bradycardia: Implications for neural control of cardiac excitability. J. Mol. Cell Cardiol. 52(3):667-76 [Abstract/Full Text].

Li, D., Lee, C.W., Buckler, K., Parekh, A., Herring, N. and Paterson, D.J. (2012) Abnormal Intracellular Calcium Homeostasis in Sympathetic Neurons From Young Prehypertensive Rats. Hypertension 59(3):642-9 [Abstract/Full Text].

Adlam, D., Herring, N., Douglas, G., De Bono, J.P., Li, D., Danson, E.J., Tatham, A., Lu, C.J., Jennings, K.A., Cragg, S.J., Casadei, B., Paterson, D.J. and Channon, K.M. (2012) Regulation of beta-Adrenergic Control of Heart Rate by GTP-Cyclohydrolase 1 (GCH1) and Tetrahydrobiopterin. Cardiovasc. Res. 93(4):694-701 [Abstract/Full Text].

Basnayake, S.D., Green, A.L. and Paterson, D.J. (2012) Mapping the Central Neurocircuitry that Integrates the Cardiovascular Response to Exercise in Humans. Exp. Physiol. 97(1):29-38 [Abstract/Full Text].

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PUBLICATIONS FOR 2011

Adlam, D., De Bono, J.P., Danson, E.J., Zhang, M.H., Casadei, B., Paterson, D.J. and Channon, K.M. (2011) Telemetric analysis of haemodynamic regulation during voluntary exercise training in mouse models. Exp. Physiol. 96(11):1118-28[Abstract/Full Text].

Wagner, P.D. and Paterson, D.J. (2011) Physiology: found in translation. J. Physiol. 15(589):3899-900 [Abstract/Full Text], [Podcast].

Paterson, D.J. (2011) The Journal of Physiology: over 130 years of communicating fundamental discovery in physiology. J. Physiol. 589(13):3049-50 [Abstract/Full Text].

Bradley, C.P., Clayton, R.H., Nash, M.P., Mourad, A., Hayward, M., Paterson, D.J. and Taggart, P. (2011) Human ventricular fibrillation during global ischemia and reperfusion: paradoxical changes in activation rate and wavefront complexity. Circulation: Arrhythmia & Electrophysiology 4(5):684-91 [Abstract/Full Text].

Bradley, C., Bowery, A., Britten, R., Budlemann, V., Camara, O., Christie, R., Cookson, A., Frangi, A.F., Gamage, T.B., Heidlauf, T., Kirttian, S., Ladd, D. Little, C., Mithraratne, K., Nash, M., Nickerson, D., Nielsen, P., Nordbo, O., Omholt, S., Pashaei, A., Paterson, D., Rajagopal, V., Reeve, A., Rohrle, O., Safaei, S., Sebastian, R., Steghoffer, M., Wu, T., Yu, T., Zhang, H., and Hunter, P. (2011) OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project. Prog. Biophy. Mol. Biol. 107(1):32-47 [Abstract/Full Text].

Clayton, R.H., Nash, M.P., Bradley, C.P., Panfilov, A.V., Paterson, D.J. and Taggart, P. (2011) Experiment-model interaction for analysis of epicardial activation during human ventricular fibrillation with global myocardial ischaemia. Prog. Biophy. Mol. Biol. 107(1):101-11 [Abstract/Full Text].

Tao, T., Paterson, D.J. and Smith, N.P. (2011) A model of cellular cardiac-neural coupling capturing the sympathetic control of sinoatrial node excitability in normotensive and hypertensive rats. Biophysical J. 101(3):594-602 [Abstract].

Carter H.H., Dawson E.A., Cable N.T., Basnayake S., Aziz T.Z., Green A.Li., Paterson D.J., Lind C.R., Thijssen D.H. and Green D.J. (2011) Deep Brain Stimulation of the Periaqueductal Grey Induces Vasodilation in Humans. Hypertension57(5):e24-25 [Abstract/Full Text].

Basnayake, S.D., Hyam, J.A., Pereira, E.A., Schweder, P.M., Brittain, J-S., Aziz, T.Z., Green, A.L. and Paterson, D.J. (2011) Identifying cardiovascular neurocircuity involved in the exercise pressor reflex in humans using functional neurosurgery. J. Appl. Physiol. 110:881-891 [Abstract/Full Text]. Editorial Alheid, G.F., Iwamoto, G. A., Thomas, Jr., J.X., and McCrimmon, D.R. (2011) Turning the PAGe on central control of the exercise pressor reflex in humans J. Appl. Physiol 110:867-868

Herring, N., Lee, C.W., Sunderland, N., Wright, K. and Paterson, D.J. (2011) Pravastatin normalizes peripheral cardiac sympathetic hyperactivity in the spontaneously hypertensive rat. J. Mol. Cell. Cardiol. 50(1):99-106 [Abstract/Full Text - Subscription required for full text].

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PUBLICATIONS FOR 2010

Drummond, G.B., Paterson, D.J. and McGrath J.C. (2010) ARRIVE: new guidelines for reporting animal research. J. Physiol. 588(Pt 14):2517 [Full Text].

Hunter, P., Smaill, B., Smith, N. and Paterson, D.J. (2010) The heart physiome project. WIREs System Biology and Medicine In press.

Pereira, E.A., Lu, G., Wang, S., Schweder, P.M., Hyam, J.A., Stein, J.F., Paterson, D.J., Aziz, T.Z. and Green, A.L. (2010) Ventral periaqueductal grey stimulation alters heart rate variability in humans with chronic pain. Exp. Neuro. 223(2):574-581 [Abstract/Full Text].

Pereira, E.A., Wang, S., Paterson, D.J., Stein, J.F., Aziz, T.Z. and Green, A.L. (2010) Sutained reduction of hypertension by deep brain stimulation. J. Clin Neurosci. 17(1):124-127 [Abstract / Full text].

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PUBLICATIONS FOR 2009

Lee, C.W., Li, D., Channon, K.M. and Paterson, D.J. (2009) L-arginine supplementation reduces cardiac noradrenergic neurotransmission in spontaneously hypertensive rats. J. Mol. Cell Cardiol. 47(1):149-55 [Abstract/Full Text].

Smith, N.P., Hunter, P.J. and Paterson, D.J. (2009) The cardiac physiome: at the heart of coupling models to measurement [Abstract / Full Text]

Wang, L., Li, D., Dawson, T.A. and Paterson, D.J. (2009) Long term effect of nNOS overexpression on cardiac neurotransmission mediated by a lentiviral vector. J. Physiol. 587.14:3629-3637 [Abstract / Full text].

Smith, N.P., Hunter, P.J. and Paterson, D.J. (2009) The cardiac physiome: at the heart of coupling models to measurement. Exp. Physiol. 94(5):469-71 [No abstract available/Full text ].

Danson, E.J., Li, D., Wang, L., Dawson, T.A. and Paterson, D.J. (2009) Targeting cardiac sympathovagal imbalance using gene transfer of nitric oxide synthase. J. Mol. Cell Cardiol. 46(4):482-9 [Abstract/Full Text - subscription required for full text].

Ten Tusscher, K.H., Mourad, A., Nash, M.P., Clayton, R.H., Bradley, C.P., Paterson D.J., Hren, R.H., Hayward, M., Panfilov, A.V. and Taggart, P. (2009) Organization of ventricular fibrillation in the human heart: experiments and models. Exp. Physiol. 94(5):553-62 [Abstract/Full Text - subscription required for full text].

Bursill, C.A., McNeill, E., Wang, L., Hibbert, O.C., Wade-Martins, R., Paterson, D.J., Greaves, D.R. and Channon, K.M. (2009) Lentiviral gene transfer to reduce atherosclerosis progression by long-term CC-chemokine inhibition. Gene Ther.16(1):93-102 [Abstract/Full Text - subscription required for full text].

Herring, N. and Paterson, D.J. (2009) Neuromodulators of peripheral cardiac symatho-vagal balance. Exp. Physiol.94:46-53 [Abstract/Full Text - subscription required for full text].

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PUBLICATIONS FOR 2008

Dawson, T.A., Li, D., Woodward, T.D., Barber, Z.E., Wang, L. and Paterson, D.J. (2008) Cardiac Cholinergic NO-cGMP Signalling Following Acute Myocardial Infarction and nNOS Gene Transfer Am. J. Physiol. Heart Circ. Physiol.295(3):H990-H998 [Abstract/Full Text - subscription required for full text].

Green, A.L. and Paterson, D.J. (2008) Identifying neurocircuitry controlling cardiovascular function in humans using functional neurosurgery: implications for exercise control. Exp. Physiol. 93(9):1022-1028 [Abstract/Full Text - subscription required for full text].

Paterson, D.J. (2008) Celebrating 100 years of publishing discovery in physiology 1908-2008. Exp. Physiol. 93(1):1-15[Abstract/Full Text - subscription required for full text].

Herring, N., Lokale, M.N., Danson, E.J., Heaton, D.A., and Paterson, D.J. (2008) Neuropeptide Y reduces acetylcholine release and vagal bradycardia via a Y2 receptor-mediated, protein kinase C-dependent pathway. J Mol Cell Cardiol.44(3):477-485 [Abstract/Full Text - subscription required for full text]. Editorial Protas, L. and Robinson, R.B. (2008) Dissecting the NPY signaling cascade between cardiac sympathetic and parasympathetic nerves. J Mol Cell Cardiol.44(3):470-472 [Abstract/Full Text - subscription required for full text].

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PUBLICATIONS FOR 2007

Herring, N., and Paterson, D.J. (2007) Common NOS1AP Variants Are Associated With a Prolonged QTc Interval in the Rotterdam Study Circulation 116 e564 [Letter to Editor - subscription required for full text]. Response to letter Aarnoudse, A-J.L.H.J., Straus, S.M.J.M., Hofman, A., Uitterlinden, A.G., Witteman, J.C.M., and Stricker, B.H.C. (2007) Circulation 116 e565 [Response to letter - subscription required for full text].

Wang, L., Henrich, M., Buckler, K., McMenamin, M., Mee, C.J., Sattelle, D.B., and Paterson, D.J. (2007) Neuronal nitric oxide synthase gene transfer decreases [Ca2+]i in cardiac sympathetic neurons J Mol Cell Cardiol. 43(6):717-25[Abstract/Full Text - subscription required for full text].

Li, D., Wang, L., Chee-Wan, L., Dawson, T.A., and Paterson, D.J. (2007) Noradrenergic Cell Specific Gene Transfer With Neuronal Nitric Oxide Synthase Reduces Cardiac Sympathetic Neurotransmission in Hypertensive Rats. Hypertension50(1):69-74 [Abstract/Full Text - subscription required for full text].

Green, A.L., Wang, S., Bittar, R.G., Owen, S.L.F., Paterson, D.J., Stein, J.F., Bain, P.G., Shlugman, D., and Aziz, T.Z. (2007) Deep brain stimulation: A new treatment for hypertension? J. Clinical Neuroscience 14(6):592-595 [Abstract/Full Text - subscription required for full text].

Heaton, D.A., Li, D., Almond, S.C., Dawson, T.A., Wang, L., Channon, K.M., and Paterson, D.J. (2007) Gene Transfer of nNOS into Intracardiac Ganglia Reverses Vagal Impairment in Hypertensive Rats Hypertension 49:380-388 [Abstract/Full Text - subscription required for full text].

Green, A.L., Wang, S., Owen, S.L., Bain, P.G., Stein, J.F., Guz, A., Aziz, T.Z., and Paterson, D.J. (2007) Identifying cardiorespiratory neurocircuitry involved in central command during exercise in humans. J. Physiol. 578.2:605-612[Abstract/Full Text - subscription required for full text]. Editorial Secher, N.H. (2007) Central command and the onset of exercise. J. Physiol. 578.2:375-376 [Abstract/Full Text - subscription required for full text].

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PUBLICATIONS FOR 2006

Green, A.L., Wang, S., Owen, S.L., Xie, K., Bittar, R.G., Stein, J.F., Paterson, D.J., and Aziz, T.Z. (2006) Stimulating the human midbrain to reveal the link between pain and blood pressure. Pain 124(3):349-59 [Abstract/Full Text - subscription required for full text].

Heaton, D.A., Lei, M., Li, D., Golding, S., Dawson, T.A., Mohan, R.M., and Paterson, D.J. (2006) Remodelling of Cardiac Pacemaker I_CaL and Beta-adrenergic Responsiveness in Hypertension following nNOS Gene Transfer. Hypertension48:443-452 [Abstract/Full Text - subscribtion required for full text].

Nash, M.P., Mourad, A., Clayton, R.H., Sutton, P.M., Bradley, C.P., Haywood, M., Paterson, D.J., Taggart, P. (2006) Evidence for multiple mechanisms in human ventricular fibrillation. Circulation Aug 8;114(6):536-42 [Abstract/Full Text - subscription required for full text]

Green, A.L., Wang, S., Owen, S.L., Paterson, D.J., Stein, J.F. and Aziz, T.Z. (2006) Controlling the heart via the brain: a potential new therapy for orthostatic hypotension. Neurosurgery 58(6):1176-83 [Abstract/Full Text - subscription required for full text]

Wang, L., Li, D., Plested, C.P., Dawson, T.D., Teschemacher, A. and Paterson, D.J. (2006) Noradrenrgic neuron-specific overexpression of nNOS in cardiac sympathetic nerves decreases neurotransmission. J Mol Cell Cardiol. Aug;41(2):364-70 [Abstract/Full Text - subscription required for full text]

Herring, N. and Paterson, D.J. (2006) ECG diagnosis of accute ischaemia and infarction: past, present and future. QJMVol 99(2) [Full text]

Nash M.P., Bradley C.P., Sutton P.M., Clayton R.H., Kallis P., Hayward M.P., Paterson D.J. and Taggart P. (2006) Whole Heart APD Restitution Properties in Cardiac Patients: A Combined Clinical and Modelling Study. Exp Physiol Feb 1 2006[Abstract/Full Text - subscription required for full text]

Danson E.J. and Paterson D.J. (2006) Reactive oxygen species and autonomic regulation of cardiac excitability. J Cardiovasc Electrophysiol. vol 17 p 1-9 Suppl 1. April. [Abstract/Full text]

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PUBLICATIONS FOR 2005

De Bono J.P., Adlam D., Paterson D.J. and Channon, K.M. (2005) Novel quantitative phenotypes of exercise training in mouse models. Am J Physiol Regul Integr Comp Physiol. Dec 8 2005 [Abstract/Full Text - subscription required for full text]

Green A.L., Wang S., Owen S.L.F., Xie K., Liua X., Paterson D.J., Stein J.F., Bain P.G. and Aziz T.P.(2005) Deep brain stimulation can regulate arterial blood pressure in awake humans. Neuroreport 16(16): 1741-1745 [Abstract/Full Text - subscription required for full text]

Paterson D.J. (2005) Targeting arterial chemoreceptor over-activity in heart failure with a gas. Circ Res. 97: 201-203 [PDF Abstract/Full Text - subscription required]

Danson, E.J.F., Zhang, Y.H., Sears, C.E., Edwards, A.R., Casadei, B., & Paterson, D.J. (2005) Disruption of inhibitory G-proteins mediates a reduction in atrial beta-adrenergic signaling by enhancing eNOS expression. Cardiovas Res.67(4):613-23 [Abstract/Full Text]. Editorial Muller, F.U. (2005) Increased eNOS expression as a compensatory mechanism reducing B-adrenergic responsiveness? Cardiovasc. Res.. 67(4):575-577 [Abstract/Full Text - subscription required for full text].

Heaton, D.A., Golding, S., Bradley, C.P., Dawson, T.A., Cai, S., Channon, K.M. & Paterson, D.J. (2005) Targeted nNOS gene transfer into the cardiac vagus rapidly increases parasympathetic function in the pig. J. Mol. Cell. Cardiol. 39(1):159-64 [Abstract/Full Text]

Danson, E.J.F. & Paterson, D.J. (2005) Cardiac neurobiology of nitric oxide synthases. Ann NY Acad Sci 1047:1-14. [Full Text]

Danson, E.J., Choate, J.K. & Paterson, D.J. (2005) Cardiac nitric oxide: emerging role for nNOS in regulating physiological function. Pharmacol Therap. 106(1):57-74 [Full Text]

Paterson, D.J. & Coote, J.H. (2005) Neural control of cardiac function. In Peripheral Neuropathy edited by P.J. Dyck & P.K. Thomas. Vol 1 pp 217-232

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PUBLICATIONS FOR 2004

Opie, L.H. & Paterson, D.J. Blood pressure and peripheral circulation, in Heart physiology from cell to circulation, L.H. Opie, Editor. 2004, Lippincott Williams & Williams: Philadelphia. p. 431-459.

Opie, L.H. & Paterson, D.J. Cardiac output and exercise, in Heart physiology from cell to circulation, L.H. Opie, Editor. 2004, Lippincott Williams & Williams: Philadelphia. p. 460-484.

Danson, E.J., Mankia, K.S., Golding, S., Dawson,T., Everatt, L., Cai, S.J., Channon, K.M. & Paterson, D.J. (2004) Impaired regulation of neuronal NOS and heart rate during exercise in mice lacking one nNOS allele. J Physiol.558(3):963-974  [ Full Text]

*Mohan, R.M.M., *Golding, S., Heaton, D.A., Danson, E.J.F. & Paterson, D.J. (2004). Targeting neuronal nitric oxide synthase with gene transfer to modulate cardiac autonomic function. Prog. Biophys. Mol. Biol. 84:321-344 [Full text]
*equal contribution 

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PUBLICATIONS FOR 2003

Nash, M.P., Bradley, C.P. & Paterson, D.J. (2003). Imaging electrocardiographic dispersion of depolarization and repolarization during ischemia:simultaneous body surface and epicardial mapping. Circulation 107:2257-2263. [Abstract / Full text]

Danson, E.J.F. & Paterson, D.J. (2003) Enhanced neuronal nitric oxide synthase expression is central to cardiac vagal phenotype in exercise-trained mice J. Physiol. 546(1):225-232.  [Full Text]

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PUBLICATIONS FOR 2002

Mohan R.M., Heaton D.A., Danson E.J.F., Krishnan S.P.R., Cai S., Channon K.M. & Paterson D.J. (2002) Neuronal Nitric Oxide Synthase Gene Transfer Promotes Cardiac Vagal Gain of Function. Circulation Research 91(12):1089-1091. [Abstract] [Full Text] [PDF Reprint 252KB]

Paton, J.R.F., Kasparov, S. & Paterson, D.J. (2002) Nitric oxide and autonomic control of heart rate: A question of specificity. Trends in Neuroscience 25(12):626-631. [Abstract] [Full Text]

Herring, N., Danson, E.J. & Paterson, D.J. (2002). Cholinergic control of of heart rate by nitric oxide is site-specific. News in Physiol. Sci.17(5):202-206. [Full Text] [PDF Reprint 980KB]

Herring, N. & Paterson, D.J. (2002). Endothelial nitric oxide synthase and heart rate. Circulation 106(2):e5. [Full Text][PDF Reprint 14KB]

Herring, N., Zaman, J.A.B. & Paterson, D.J. (2002). Particulate guanylyl cyclase and cholinergic control of cardiac excitability is site specific. Cardiovas. Res. 54(3):697-698. [Full Text]

Thornton, J.M., Aziz, T., Schlugman, D. & Paterson, D.J. (2002). Electrical stimulation of the midbrain increases heart rate and arterial blood pressure in awake humans. J. Physiol. 593(2):615-621. [Full Text]

Nash, M.P., Bradley, C.P., Kardos, A., Pullan, A.J. & Paterson, D.J. (2002). An experimental model to correlate simultaneous body surface and epicardial electropotential recordings in-vivo. Chaos, Solitons and Fractals 13(8):1735-1742. [Full Text]

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PUBLICATIONS FOR 2001

David J. Paterson GL Brown Prize Lecture (2001) Nitric Oxide and the Autonomic Regulation of Cardiac Excitability The Physiological Society 
Exp. Physiol. 86.1:1-12. [Full text]

Herring, N., Rigg, L., Terrar, D.A. & Paterson D.J. (2001). NO-cGMP pathway increases the hyperpolarisation activated current, If, and heart rate during adrenergic stimulation. Cardiovas. Res. 52(3):446-453. [Abstract]

Pullan, A.J., Cheng, L.K., Nash, M.P., Bradley, C.P. & Paterson, D.J. (2001). Noninvasive electrical imaging of the heart: Theory and model development. Ann. Biomed. Eng. 29(10):817-836. [Abstract]

Herring, N., Zaman, J.A.B. & Paterson, D.J. (2001). Natriuretic peptides like NO facilitate cardiac vagal neurotransmission and bradycardia via a cGMP pathway. Am. J. Physiol. 281(6):H2318-H2327. [Abstract] [Full Text]

Choate, J.K., Danson, E.J.F., Morris, J.F. & Paterson, D.J. (2001). Peripheral vagal control of heart rate is impaired in neuronal NOS knockout mice. Am. J. Physiol. 281(6):H2310-H2317. [Abstract] [Full Text]

Pullan, A.J., Paterson, D.J. & Greensite, F. (2001). Non-invasive imaging of cardiac electrophysiology. Phil. Trans. R. Soc. Lond. A 359(1783):1277-1286. [Abstract]

Herring, N. & Paterson D.J. (2001). NO-cGMP pathway facilitates acetylcholine release and bradycardia during vagal nerve stimulation in the guinea pig in-vitro. J. Physiol. 535(2): 507-518.  [Full Text]

Mohan, R.M., Golding, S. & Paterson, D.J. (2001). Intermittent hypoxia improves atrial tolerance to subsequent anoxia and reduces stress protein expression. Acta Physiol. Scand. 172(2):89-95. [Abstract]

Lewis, M.E., Al-Khalidi, A.H., Bonser, R.S., Clutton-Brock, T., Morton, D., Paterson, D., Townend, J.N., Coote, J.H. (2001). Vagus nerve stimulation decreases left ventricular contractility in vivo in the human and pig heart. J. Physiol. 534(2):547-552. [Full Text]

Thornton, J.M., Guz, A., Murphy, K., Griffith, A., Pedersen, D., Kardos, A., Leff, A., Adams, L., Casadei, B. & Paterson, D.J. (2001). Identification of higher brain centres that may encode the cardiorespiratory response to exercise in humans. J. Physiol. 533(3):823-836.  [Full Text]

Mohan, R.M., Golding, S. & Paterson, D.J. (2001). Intermittent hypoxia reduces nNOS expression and increases the heart rate response to cardiac sympathetic nerve stimulation in-vitro. Am. J. Physiol. 281(1): H132-H138. [Abstract] [Full Text]

Choate, J.K., Nandhabalan, M. & Paterson, D.J. (2001). Raised extracellular potassium attenuates the sympathetic modulation of sino-atrial node pacemaking in the isolated guinea-pig atria.. Exp. Physiol. 86(1):19-25. [Abstract]

Nash, M.P., Thornton, J.M., Sears, C.E., Varghese, A., O'Neill, M. & Paterson, D.J. (2001). Ventricular activation during sympathetic imbalance and its computational reconstruction. J. Appl. Physiol. 90(1):287-298. [Abstract] [Full Text]

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PUBLICATIONS FOR 2000

Almond, S.C. & Paterson, D.J. (2000). Sulphonylurea-sensitive channels and NO-cGMP pathway modulate the heart response to vagal nerve stimulation in-vitro. J. Mol. Cell. Cardiol. 32:2065-2073. [Abstract]

Nash M.P., Bradley, C.P., Cheng, L.K., Pullan, A.J. & Paterson, D.J. (2000). An in-vivo experimental-computational framework for validating ECG inverse methods. Intl. J. Bioelectromagnetism 2(2). [Journal]

Musialek, P., Rigg, L., Terrar, D.A., Paterson, D.J. & Casadei, B. (2000). Role of cGMP-inhibited phosphodiesterase and sarcoplasmic calcium in mediating the increase in basal heart rate with nitric oxide donors. J. Mol. Cell. Cardiol. 32:1831-1840. [Abstract]

Herring, N., Golding S. & Paterson, D.J. (2000). Pre-synaptic NO-cGMP pathway modulates vagal control of heart rate in isolated guinea-pig atria. J. Mol. Cell. Cardiol. 32:1795-1804. [Abstract]

Herring, N. & Paterson, D.J. (2000). Mechanisms controlling blood flow and arterial pressure. Surgery 18(3):i-vi.

Mohan, R., Choate, J.K., Golding, S., Herring, N., Casadei, B. & Paterson, D.J. (2000). Peripheral pre-synaptic pathway reduces the heart rate response to sympathetic activation following exercise training: role NO. Cardiovas. Res. 47(1):90-98. [Abstract]

Mohan, R. & Paterson, D.J. (2000). Activation of sulphonylurea-sensitive channels and the NO-cGMP pathway decreases the heart rate response to sympathetic nerve stimulation. Cardiovas. Res. 47(1):81-89. [Abstract]

Casadei, B. & Paterson, D.J. (2000). Should we still use nitrovasodilators to test baroreflex sensitivity? J. Hypertension18(1):3-6. [Full text link]

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PUBLICATIONS FOR 1999

Musialek, P., Paterson, D.J. & Casadei, B (1999). Changes in extracellular pH mediate the chronotropic responses to L-arginine. Cardiovas. Res. 43(3): 712-720. [Abstract]

Sears, C.E., Noble, P., Noble, D. & Paterson, D.J. (1999). Vagal control of heart rate is modulated by extracellular potassium. J. Auton. Nerv. Syst. 77(2-3):164-171. [Abstract]

Heinert, G., Nye, P.C.G. & Paterson, D.J. (1999). Nitric oxide and prostaglandin pathways interact in the regulation of hypercapnic cerebral vasodilitation. Acta Physiol. Scand. 166:183-193. [Abstract]

Barlow, C.W., Long, J.E., Manga, P., Meyer, T.E., Paterson, D.J. & Robbins, P.A. (1999). Exercise-induced hyperkalemia and concentration of Na,K-pumps in skeletal muscle in mitral stenosis: effect of balloon mitral valvotomy. J. Heart Valve Dis. 8(4):430-439. [Abstract]

Hogan, N.A., Casadei, B. & Paterson, D.J. (1999). Nitric oxide donors can activate heart rate independent of autonomic activation. J. Appl. Physiol. 87(1): 97-103. [Abstract] [Full Text]

Hogan N., Kardos, A., Paterson, D.J. & Casadei, B. (1999). Effect of exogenous nitric oxide on baroreflex function in humans. Am. J. Physiol. 277:H221-H227.  [Full Text]

Choate, J & Paterson D.J. (1999).  Nitric oxide inhibits the positive chronotropic and inotropic responses to sympathetic nerve stimulation in the isolated guinea pig atria. J. Auton. Nerv. Syst. 75(2-3):100-108. [Full Text]

Sears, C.E., Choate, J.K. & Paterson D.J. (1999). NO-cGMP pathway accentuates the decrease in heart rate caused by cardiac vagal nerve stimulation. J. Appl. Physiol. 86(2):510-516. [Abstract] [Full Text]

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PUBLICATIONS FOR 1998

Heinert, G., Casadei, B. & Paterson D.J. (1998). Hypercapnic and hypoxic cerebral blood flow in spontaneously hypertensive rats. J. Hypertension 16(10):1491-1498. [Abstract]

Sears, C.E., Choate, J. & Paterson (1998). Effect of nitric oxide synthase inhibition on the sympathovagal control of heart rate. J. Auton. Nerv. Syst. 73(1):63-73. [Abstract]

Barlow, C.W., Davey, P.P., Qayyum, M.S., Conway, J., Paterson, D.J. & Robbins, P.A. (1998). Leg blood flow and increased potassium release during exercise in chronic heart failure: effect of physical training. J. Card. Fail. 4(2):105-114. [Abstract]

Sears C.E., Choate J.K., Paterson D.J. (1998). Inhibition of nitric oxide synthase slows heart rate recovery from cholinergic activation. J. Appl. Physiol. 84(5):1596-1603. [Abstract] [Full Text]

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PUBLICATIONS FOR 1997

Musialek, P., Lei, M., Brown ,H.F., Paterson, D.J. & Casadei, B. (1997). Nitric oxide can increase heart rate by stimulating the hyperpolarization-activated inward current, If. Circ. Res. 81(1):60-68. [Abstract] [Full Text]

O'Neill, M., Sears, C.E. & Paterson, DJ. (1997). Interactive effects of K+, acid, norepinephrine, and ischaemia on the heart: implications for exercise. J. Appl. Physiol. 82(4):1046-1052. [Abstract]

Barlow, C.W., Qayyum, M.S., Davey, P.P., Paterson, D.J. & Robbins, P.A. (1997). Effect of heart failure and physical training on the acute ventilatory response to hypoxia at rest and during exercise. Respiration 64:131-137. [Abstract]

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PUBLICATIONS FOR 1996

Paterson, D.J. (1996). Role of potassium in the regulation of systemic physiological function during exercise. Acta Physiol Scand. 156(3):287-294. [Abstract]

Ryan, D. M. & Paterson D.J. Restoration of cardiac contraction by angiotensin II during raised [K+]o in the rabbit. Acta Physiol. Scand.156, 419-427. [Abstract]

Reid, J.M. & Paterson, D.J. (1996). Role of K+ in regulating hypoxic cerebral blood flow in the rat: effect of glibenclamide and ouabain. Am. J. Physiol. 270:H45-H52. [Abstract]

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PUBLICATIONS FOR 1995

Reid, J.M., Davies, A.G., Ashcroft, F.M. & Paterson, D.J. (1995). Effect of L-NMMA, cromakalim, and glibenclamide on cerebral blood flow in hypercapnia and hypoxia. Am. J. Physiol. 269:H916-922. [Abstract]

O'Neill, M., Ryan, D.M. & Paterson, D.J. (1995). Effect of verapamil on restoration of cardiac performance in raised [K+]oby adrenergic stimulation in the rabbit. Acta Physiol. Scand. 154: 367-376. [Abstract]

Leitch, S.P., Sears, C.E. Brown, H.F. & Paterson, D.J. (1995). Effects of high potassium and the bradycardic agents ZD7288 and cesium on heart rate of rabbits and guinea pigs. J. Cardiovas. Pharmacol. 25(2):300-306. [Abstract]

O'Neill, M. & Paterson, D.J. (1995). Role of the sympathetic nervous system in maintaing cardiovascular performance during hyperkalaemia in the anaesthetised pig. Acta Physiol. Scand. 153(1):1-11. [Abstract]

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PUBLICATIONS FOR 1994

Leitch, S.P. & Paterson D.J. (1994). Role of Ca2+ in protecting the heart from hyperkalaemia and acidosis in the rabbit: implications for exercise. J. Appl. Physiol. 77(5):2391-2399. [Abstract]

Leitch, S.P. & Paterson D.J. (1994). Interactive effects of potassium, acid and catecholamines on the isolated rabbit heart: implications for exercise. J. Appl. Physiol. 77:1164-1171. [Abstract]

Ryan, D.M. & Paterson, D.J. (1994). Effect of ouabain and verapamil on restoration of contraction by adrenaline during high K+ in the frog heart. Acta Physiol. Scand. 151(3):417-419.[Journal]

Qayyum, M.S., Barlow, C.W., Paterson, D.J. & Robbins, P.A. (1994). Effect of raised potassium on ventilation in euoxia, hypoxia and hyperoxia at rest and during light exercise in man. J. Physiol. 476(2):365-372. [Abstract]

Barlow, C.W., Qayyum, M.S., Davey, P.P., Conway, J., Paterson, D.J., Robbins, P.A. (1994). Effect of physical training on exercise-induced hyperkalaemia chronic heart failure. Relation with ventilation and catecholamines. Circulation89(3):1144-1152. [Abstract]

Barlow, C.W., Qayyum, M.S., Davey, P.P., Paterson, D.J., Robbins, P.A. (1994). Effect of hypoxia on arterial potassium concentration at rest and during exercise in man. Exp. Physiol. 79(2):257-260. [Abstract]

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PUBLICATIONS FOR 1993

Reid, J.M., Paterson, D.J., Ashcroft, F.M. & Bergel, D.H. (1993). The effect of tolbutamide on cerebral blood flow in hypoxia and hypercapnia in the anaesthetised rat. Pflueg. Arch. 425:362-364. [Abstract]

Qayyum, M.S., Freemantle, C.A.J., Carey, C.J., Page, B.C., Soper, N., Paterson, D.J. & Robbins, P.A. (1993). Potassium loss from skeletal muscle during exercise in man: a radioisotope study. Exp. Physiol. 78(5):591-614. [Abstract]

O'Neill, M., Dorrington, K.L. & Paterson, D.J. (1993). Cardiac sympathetic nerve stimulation enhances cardiovascular performance in the anaesthetised pig. Exp. Physiol. 78(4):549-552. [Abstract]

Paterson, D.J., Rogers, J., Powell, T. & Brown, H.F. (1993). Effects of catecholamines on the ventricular myocyte action potential in raised extracellular potassium. Acta Physiol. Scand. 148(2):177-186. [Abstract]

 
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PUBLICATIONS FOR 1992

Paterson, D.J., Blake, G.J., Leitch, S.P., Phillips, S.M. & Brown, H.F. (1992). Effects of catecholamines and potassium on cardiovascular performance in the rabbit. J. Appl. Physiol. 73(4):1413-1418. [Abstract]

Paterson, D.J., Vejlstrup, N., Willford, D. & Hogan, M.C. (1992). Effect of a sulphonylurea on dog skeletal muscle performance during fatiguing work. Acta Physiol. Scand. 144(3):399-400. [Journal]

Paterson, D.J., Dorrington, K.L, Bergel, D.H., Kerr, G., Miall, R.C., Stein, J.F. & Nye, P.C.G. (1992). Effect of potassium on ventilation in the rhesus monkey. Exp. Physiol. 77(1):217-220. [Abstract]

Carlile, S. & Paterson, D.J. (1992). The effect of chronic hypoxia on human auditory sensitivity. Aviat. Space Environ. Med. 63(12):1093-1097. [Abstract]

Carlile, S., Bascom, D.A. & Paterson, D.J. (1992). The effect of acute hypoxia on the latency of the human auditory brainstem evoked response. Acta Otolaryngol. 112:939-945. [Abstract]

Clement, I.D., Bascom, D.A., Conway, J., Dorrington, K.L., O'Connor, D.F., Painter, R., Paterson, D.J. & Robbins, P.A. (1992). An assessment of central-peripheral chemoreflex interaction in humans. Respir. Physiol. 88:87-100. [Abstract]

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PUBLICATIONS FOR 1991

Paterson, D.J. and Nye, P.C.G. (1991). Effect of oxygen on potassium-excited ventilation in the decerebrate cat. Respir. Physiol. 84:223-230. [Abstract]

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PUBLICATIONS FOR 1990

Paterson, D.J., Friedland, J.S., Bascom, D.A., Clement, I.D., Cunningham, D.A., Painter, R. & Robbins, P.A. (1990). Changes in arterial potassium and ventilation during exercise in normal subjects and subjects with McArdle's syndrome. J. Physiol. 429:339-348. [Abstract]

Robbins, P.A., Conway, J., Cunningham, D.A., Khamnei, S. & Paterson, D.J. (1990). A comparison of indirect methods for continuous estimation of arterial PC02 in men. J. Appl. Physiol. 68(4):1727-1731. [Abstract]

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PUBLICATIONS FOR 1989

Paterson, D.J., Robbins, P.A. & Conway, J. (1989). Changes in arterial plasma potassium and ventilation in response to exercise in man. Respir. Physiol. 78(3): 323-330. [Abstract]

Robertson, B.E., Paterson, D.J., Peers, C. & Nye, P.C.G. (1989). Tolbutamide reverses hypoxic pulmonary vasoconstriction in isolated rat lungs. Q. J. Exp. Physiol. 74:959-962. [Abstract]

Paterson, D.J., Friedland, J.S., Oliver, D.O. & Robbins, P.A. (1989). The ventilatory response to lowering potassium with dextrose and insulin in patients with hyperkalaemia. Respir. Physiol. 76(3):393-398. [Abstract]

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PUBLICATIONS FOR 1988

Paterson, D.J. & Nye, P.C.G. (1988). The effect of beta adrenergic blockade on carotid body chemoreceptors during hyperkalaemia in the cat. Respir. Physiol. 74: 229-238. [Abstract]

Paterson, D.J., Estavillo, J.A. & Nye, P.C.G. (1988). The effect of hypoxia on plasma potassium concentration and the excitation of arterial chemoreceptors in the cat. Q. J. Exp. Physiol. 73:623-625. [Abstract]

Burger, R.E., Estavillo, J.A., Kumar, P., Nye, P.C.G. & Paterson, D.J. (1988). Effects of oxygen, carbon dioxide and potassium on steady-state discharge of cat carotid body chemoreceptors. J. Physiol. 401:519-531. [Abstract]

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PUBLICATIONS FOR 1987

Paterson, D.J., Wood, G.A., Marshall, R.N. & Harrison, A.B. (1987). Entrainment of respiratory frequency to exercise rhythm during hypoxia. J. Appl. Physiol. 62(5):1767-1771. [Abstract]

Paterson, D.J., Pinnington, H., Pearce, A.R. & Morton, A.R. (1987). Maximal exercise cardiorespiratory responses of men and women during acute exposure to hypoxia. Aviat. Space Environ. Med. 58(3):243-247. [Abstract]

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PUBLICATIONS FOR 1986

Paterson, D.J., Wood, G.A., Morton, A.R. & Henstridge, J.D. (1986). The entrainment of ventilation frequency to exercise rhythm. Eur. J. Appl. Physiol. (Occup. Physiol.) 55(5): 530-537. [Abstract]

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REFEREED REVIEWS

Paterson, D.J. (1997). Potassium and breathing in exercise. Sports Medicine 23(3): 149-163. [Summary]

Paterson, D.J. (1996). Antiarrhythmic mechanisms during exercise. J. Appl. Physiol. 80(6): 1853-1862. [Abstract]

Paterson, D.J. (1992). Potassium and ventilation in exercise. J. Appl. Physiol. 72: 811-820. [Abstract]

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BOOK CHAPTERS

Heinert, G., Paterson, D.J. , Bisgard, G.E., Xia, N., Painter, R. & Nye, P.C.G. (1995). The excitation of the carotid body chemoreceptors of the cat by potassium and noradrenaline. In: Modelling and Control of Ventilation. Advances in Experimental Medicine and Biology, Vol. 393. Plenum Publications, London, pp.323-330.

Paterson, D.J. & Nye, P.C.G. (1994). Reflexes arising from the arterial chemoreflex In: Arterial Chemoreceptors Cell to System. Advances in Experimental Medicine and Biology Vol 360 Plenum Publications London. Edited by R.G. O'Regan, D.S. McQueen, P Nolan and D.J. Paterson. Plenum Publications, London, pp.71-86.

Paterson, D.J. & Nye, P.C.G. (1993). Effects of PO2 on the ventilatory responses of the cat and monkey to changes in arterial potassium. In: Neurobiology and cell physiology of chemoreception. Advances in Experimental Medicine and Biology, Vol. 337. Ed. P.G. Data, H. Acker & S. Lahiri. Plenum, New York, pp.365-369

Paterson, D.J. (199?). Altered Gravity In: Physiology. Edited by Blakemore, C., Ellory, J.C., Morris, J., Nye, P.C.G. & Miall, C. Gower.

Paterson, D.J., Peers, C.P. & Nye, P.C.G. (1990). Interactions between the effects of oxygen and potassium at the carotid body, and its pattern of discharge in response to these and other stimuli in the cat. In: Arterial Chemoreception. Ed. C. Eyzaguirre, S. Fidone, S. Lahiri & R.S. Fitzgerald. Springer-Verlag, New York, pp.270-278.

Paterson, D.J. & Nye, P.C.G. (1989). Increased arterial potassium levels may contribute to the drive to breathe at very high altitude. In Respiratory Control: A Modelling Perspective. Eds Swanson, G.A., Grodins, F.S. & Hughson, R.L. Plenum publications, pp.191-200.

R.S. Fitzgerald. Springer-Verlag, New York, pp.270-278.

Paterson, D.J. & Nye, P.C.G. (1989). Increased arterial potassium levels may contribute to the drive to breathe at very high altitude. In Respiratory Control: A Modelling Perspective. Eds Swanson, G.A., Grodins, F.S. & Hughson, R.L. Plenum publications, pp.191-200.

Paterson, D.J., Robbins, P.A., Conway, J. & Nye, P.C.G. (1989). Does arterial potassium contribute to exercise hyperpnoea? In Respiratory Control: Modelling Perspective. Eds Swanson, G.A., Grodins, F. & Hughson, R.L. Plenum publications, pp.11-21.

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