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The dominantly inherited cerebellar ataxias are a clinically and genetically heterogeneous group of neurodegenerative disorders. Studies using mouse models as well as recent genetic and transcriptomic human findings point to an important role for TRPC3 signaling in cerebellar ataxia.

Original publication

DOI

10.1007/s12311-015-0663-y

Type

Journal article

Journal

Cerebellum

Publication Date

12/2017

Volume

16

Pages

877 - 879

Keywords

Ataxia, Calcium signaling, Purkinje cell, TRPC3, mGluR1, Animals, Cerebellar Ataxia, Humans, TRPC Cation Channels