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Ligands for peroxisome proliferator-activated receptors alpha (PPARalpha) are clinically used for the treatment of patients with hyperlipidemia. As we have previously shown, a synthetic ligand of PPARalpha, fenofibrate, has a stimulatory effect on insulin secretion in clonal hamster insulinoma beta-cell line HIT-T15 cells. We have also demonstrated that fenofibrate directly inhibits ATP-sensitive potassium (K(ATP)) channels, an effect independent of PPARalpha. In this study, fenofibrate was shown to be able to reduce voltage-dependent K(+) (K(v)) channel currents in voltage-independent manner. Therefore, fenofibrate may modulate insulin secretion not only via inhibition of K(ATP) channels but also via reduction of the K(v) channel current.

Type

Journal article

Journal

Gen Physiol Biophys

Publication Date

12/2006

Volume

25

Pages

455 - 460

Keywords

Animals, Cell Line, Cricetinae, Dose-Response Relationship, Drug, Fenofibrate, Insulin-Secreting Cells, Ion Channel Gating, PPAR alpha, Potassium Channels