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The Physiome Project of the International Union of Physiological Sciences (IUPS) is attempting to provide a comprehensive framework for modelling the human body using computational methods which can incorporate the biochemistry, biophysics and anatomy of cells, tissues and organs. A major goal of the project is to use computational modelling to analyse integrative biological function in terms of underlying structure and molecular mechanisms. To support that goal the project is establishing web-accessible physiological databases dealing with model-related data, including bibliographic information, at the cell, tissue, organ and organ system levels. Here we discuss the background and goals of the project, the problems of modelling across multiple spatial and temporal scales, and the development of model ontologies and markup languages at all levels of biological function.

Original publication

DOI

10.1007/s00424-002-0890-1

Type

Journal article

Journal

Pflugers Arch

Publication Date

10/2002

Volume

445

Pages

1 - 9

Keywords

Anatomy, Biochemical Phenomena, Biochemistry, Biophysical Phenomena, Biophysics, Databases as Topic, Humans, Models, Biological, Software