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Ca(2+) entry through store-operated Ca(2+) release-activated Ca(2+) (CRAC) channels controls a disparate array of key cellular responses. In this review, recent work will be described that shows local Ca(2+) influx through CRAC channels has important spatial and temporal consequences on cell function. A localized Ca(2+) rise below the plasma membrane activates, within tens of seconds, catabolic enzymes resulting in the generation of the intracellular messenger arachidonic acid and the paracrine pro-inflammatory molecule LTC(4). In addition, local Ca(2+) entry can activate gene expression, which develops over tens of minutes. Local Ca(2+) influx through CRAC channels therefore has far-reaching consequences on intra- and intercellular communication.

Original publication

DOI

10.1111/j.1748-1716.2008.01919.x

Type

Journal article

Journal

Acta Physiol (Oxf)

Publication Date

01/2009

Volume

195

Pages

29 - 35

Keywords

Animals, Calcium, Calcium Channels, Cell Membrane, Mast Cells, Time Factors