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To identify those multiple sclerosis (MS) patients with disabling tremor who will benefit most from thalamotomy, measurements of frequency spectra of involuntary movements during visually guided wrist tracking were carried out in 11 consecutive patients with MS before and after ventrolateral thalamotomy. Thalamotomy was significantly more effective if patients had disruptive action tremor which appeared as a single peak in the frequency spectra. Such patients showed an average reduction of nearly 80% in tremor magnitude after thalamotomy. In comparison, surgery produced an average reduction of only 30% in 3 other patients who had action tremor but showed multiple peaks in the frequency spectra. Frequency analysis of involuntary movements identifies those MS patients with disabling tremor who benefited most from thalamotomy.

Original publication

DOI

10.1159/000056464

Type

Journal article

Journal

Stereotact Funct Neurosurg

Publication Date

2000

Volume

74

Pages

53 - 62

Keywords

Adult, Dyskinesias, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Monitoring, Intraoperative, Monitoring, Physiologic, Multiple Sclerosis, Psychomotor Performance, Stereotaxic Techniques, Thalamus, Tremor, Wrist Joint