Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Epstein-Barr virus (EBV) oriP and the EBV nuclear antigen 1 (EBNA-1) protein allow persistence of EBV-based episomes. A nuclear matrix attachment region (MAR) spans oriP and the adjacent region of the EBV genome containing the EBV-expressed RNAs. Here, we show that episomes with the MAR are retained significantly more efficiently in EBV-positive B cells than episomes containing oriP alone.

Original publication

DOI

10.1128/JVI.75.22.11249-11252.2001

Type

Journal article

Journal

J Virol

Publication Date

11/2001

Volume

75

Pages

11249 - 11252

Keywords

Attachment Sites, Microbiological, B-Lymphocytes, Genes, Viral, Herpesvirus 4, Human, Humans, Nuclear Matrix, Plasmids, RNA, Viral, Replication Origin, Tumor Cells, Cultured