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Within the past decade, extracellular vesicles have emerged as important mediators of intercellular communication, being involved in the transmission of biological signals between cells in both prokaryotes and higher eukaryotes to regulate a diverse range of biological processes. In addition, pathophysiological roles for extracellular vesicles are beginning to be recognized in diseases including cancer, infectious diseases and neurodegenerative disorders, highlighting potential novel targets for therapeutic intervention. Moreover, both unmodified and engineered extracellular vesicles are likely to have applications in macromolecular drug delivery. Here, we review recent progress in understanding extracellular vesicle biology and the role of extracellular vesicles in disease, discuss emerging therapeutic opportunities and consider the associated challenges.

Original publication

DOI

10.1038/nrd3978

Type

Journal article

Journal

Nat Rev Drug Discov

Publication Date

05/2013

Volume

12

Pages

347 - 357

Keywords

Cell Communication, Cell-Derived Microparticles, Drug Delivery Systems, Drug Therapy, Exosomes, Extracellular Space, Humans, Translational Medical Research