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Our work is narrowing the divide between a rapidly-increasing volume of genomic data and a less-rapidly expanding breadth of understanding of biological function. We seek to provide access for all biologists to the enormous predictive potential of DNA sequence data.
Our research is placed at the intersection between disease genomics, computational biology and molecular mechanism determination. We are exploiting RNA and DNA sequence data to illuminate the molecular pathoetiology of human disease. We are beginning to develop transcriptional atlases for cells and tissues in order to better understand their functional repertoires. Our primary aim is, however, to exploit all genome-scale data sets to identify or prioritise genes that are mutated in human disease. For example, we have a large programme of work investigating the genetic variants that underlie the onset of Parkinson’s disease.