- Christian Group Research Group
University Lecturer and Deputy Head of Department
Helen Christian gained a degree in Pharmacology in 1993 (University of Edinburgh) and a doctorate in Pharmacology in 1997 (University of London). She came to the Department of Human Anatomy, Oxford in 1996 funded by a one year post-doctoral fellowship before taking up a Departmental Lectureship in Human Anatomy in 1997. Since 2000 she has been a University Lecturer in Biomedicine and Fellow of St Anne’s College. She was awarded a University of Oxford Teaching Excellence Award in 2010 and an OxTalent award for innovative teaching in 2011.
Helen Christian's research interests are in the mechanisms of steroid hormone regulation of the pituitary gland, in particular the role of Annexin 1. The Annexins are a well conserved super-family of structurally related Ca2+ - and phospholipids-binding proteins with wide-ranging functions in health and disease. Annexin 1 is a 37kD protein that is induced by glucocorticoids and mediates glucocorticoid action within the host defence and neuroendocrine systems.
Binary Switching of Calendar Cells in the Pituitary Defines the Phase of the Circannual Cycle in Mammals.
Wood SH. et al, (2015), Curr Biol, 25, 2651 - 2662
Oocyte glycoproteins regulate the form and function of the follicle basal lamina and theca cells.
Christensen AP. et al, (2015), Dev Biol, 401, 287 - 298
Ultrastructural changes in lactotrophs and folliculo-stellate cells in the ovine pituitary during the annual reproductive cycle.
Christian HC. et al, (2015), J Neuroendocrinol, 27, 277 - 284
Cardiac ferroportin regulates cellular iron homeostasis and is important for cardiac function.
Lakhal-Littleton S. et al, (2015), Proc Natl Acad Sci U S A, 112, 3164 - 3169
Absence of intracellular ion channels TPC1 and TPC2 leads to mature-onset obesity in male mice, due to impaired lipid availability for thermogenesis in brown adipose tissue.
Lear PV. et al, (2015), Endocrinology, 156, 975 - 986
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