- Christian Group Research Group
University Lecturer and Deputy Head of Department
Helen Christian gained a degree in Pharmacology in 1993 (University of Edinburgh) and a doctorate in Pharmacology in 1997 (University of London). She came to the Department of Human Anatomy, Oxford in 1996 funded by a one year post-doctoral fellowship before taking up a Departmental Lectureship in Human Anatomy in 1997. Since 2000 she has been a University Lecturer in Biomedicine and Fellow of St Anne’s College. She was awarded a University of Oxford Teaching Excellence Award in 2010 and an OxTalent award for innovative teaching in 2011.
Helen Christian's research interests are in the mechanisms of steroid hormone regulation of the pituitary gland, in particular the role of Annexin 1. The Annexins are a well conserved super-family of structurally related Ca2+ - and phospholipids-binding proteins with wide-ranging functions in health and disease. Annexin 1 is a 37kD protein that is induced by glucocorticoids and mediates glucocorticoid action within the host defence and neuroendocrine systems.
An investigation into pituitary gonadotrophic hormone synthesis, secretion, subunit gene expression and cell structure in normal and mutant male mice.
Abel MH. et al, (2013), J Neuroendocrinol, 25, 863 - 875
Insulin and IGF-I inhibit GH synthesis and release in vitro and in vivo by separate mechanisms.
Gahete MD. et al, (2013), Endocrinology, 154, 2410 - 2420
Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications.
Cristante E. et al, (2013), Proc Natl Acad Sci U S A, 110, 832 - 841
Existence of long-lasting experience-dependent plasticity in endocrine cell networks.
Hodson DJ. et al, (2012), Nat Commun, 3
Existence of long-lasting experience-dependent plasticity in endocrine cell networks
Hodson DJ. et al, (2012), Nature Communications, 3
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