Neuroscience

DPAG hosts a number of internationally recognized neuroscience groups, with expertise in a wide range of experimental and computational methods

Optogenetic
Writing artificial memories with an optical remote control
 
 
Cortex vasculature
Developing cortical vasculature (green) is closely associated with the dividing cortical progenitors (red cells in blue layer) in a E14.5 mouse brain

The department has superb in-depth expertise in the anatomical, physiological and behavioural techniques required for investigating the functional neural circuitry, particularly at the level of the cerebral cortex that underlies perception and behaviour, the coding of information in those circuits and the way in which they develop and are shaped by experience. These approaches are complemented by the application of optogenetic methods for studying information processing in explanted tissues. Several groups have a particular interest in decision-making and adaptive behaviour and are studying these fundamental issues from different angles and in different experimental settings.

There is world-class expertise in:


  • a wide range of genetic model organisms
  • neuronal disease cell culture models and neuronal stem cells
  • RNAi techniques and use of viral vectors
  • optogenetic manipulation of neural circuits
  • animal models of Parkinson’s disease, Alzheimer’s disease, muscle disorders and ataxia
  • development and translation of novel molecular therapies for neuromuscular and neurodegenerative disease
  • study of auditory coding and plasticity
 

Membership of this theme: